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Synergistic effects of a new beta-adrenergic blocker (pindolol) and isosorbidedinitrate during exercise in patients with coronary insufficiency

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23 male patients with coronary insufficiency on exertion underwent standardized work tests using a bicycle ergometer. In a double blind randomized trial they received oral doses of 2 mg pindolol (LB 46), 5 mg Isosorbidedinitrate (ISO), 2 mg pindolol + 5 mg isosorbidedinitrate (LBI 25) and a placebo. LBI 25, LB 46 and ISO all produced significant increases in the work performed before symptoms and signs appeared of coronary insufficiency. The mean increase in total work was: LBI 25 69%; LB 46 49%; and ISO 33%. The corresponding figures for work performed up to the time of appearance of ST-depression were: LBI 25 115%; LB 46 87%; and ISO 54%. A moderate synergism between ISO and LB 46 was found in 17 of the 23 patients. Tiredness in the legs during work was more common in patients taking beta-blocking agents. Nine patients complained of slight headache, mostly after LBI 25 and ISO.

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Adolfsson, L., Areskog, N.-., Furberg, C. et al. Synergistic effects of a new beta-adrenergic blocker (pindolol) and isosorbidedinitrate during exercise in patients with coronary insufficiency. Eur J Clin Pharmacol 5, 37–43 (1972). https://doi.org/10.1007/BF00560894

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Key words

  • Beta adrenergic receptor blockade
  • nitrates
  • placebo
  • coronary artery disease
  • exercise test