Archives of Dermatological Research

, Volume 255, Issue 2, pp 111–121 | Cite as

Chrysanthemum allergy

III. Identification of the allergens
  • B. M. Hausen
  • K. H. Schulz


Experimental and chemical studies in guinea pigs on contact allergy caused byChrysanthemum indicum L. (Chrysanthemum of the florists) led to the isolation of several sesquiterpene lactones.

From the crude extract of dried flowers 12 fractions were obtained of which four gave strong reactions on epicutaneous application to guinea pigs sensitized with an extract of C.indicum L.

One of these allergens was identified as a sesquiterpene lactone of the guaianolide type. It is identical to Arteglasin-A derived fromArtemisia douglasiana Bess.

The occurrence of Arteglasin-A inChrysanthemum indicum L. as well as its allergenic properties are described for the first time.

These findings give rise to the assumption that the other, as yet unidentified sesquiterpene lactones of this flower also belong to the guaianolide type.


Public Health Crude Extract Lactone Chemical Study Sesquiterpene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Chemische Untersuchungen und experimentelle Teste an Meerschweinchen bezüglich der durch Chrysanthemen verursachten Kontaktallergie führten zur Isolierung mehrerer Sesquiterpenlaktone.

Aus dem Rohextrakt getrockneter Chrysanthemen wurden 12 Fraktionen isoliert, von denen vier im Epikutantest bei sensibilisierten Meerschweinchen eine stark positive Reaktion ergaben. Eins der Allergene wurde als Sesquiterpenlakton vom Guaianolid-Typ identifiziert. Es ist identisch mit Arteglasin-A ausArtemisia douglasiana Bess.

Sowohl das Vorkommen von Arteglasin-A inChrysanthemum indicum L. als auch seine allergene Wirkung werden hier das erste Mal beschrieben.

Die Untersuchungsbefunde lassen vermuten, daß die anderen bisher nicht identifizierten Sesquiterpenlaktone ebenfalls dem Guaianolid-Typ angehören.


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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • B. M. Hausen
    • 1
  • K. H. Schulz
    • 1
  1. 1.Department of Dermatology, Division of AllergologyUniversity HospitalHamburgGermany

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