European Journal of Clinical Pharmacology

, Volume 35, Issue 3, pp 319–321

Attenuation of cutaneous reactivity to histamine by cetirizine and dexchlorpheniramine

  • F. O. Müller
  • J. J.deK Botha
  • M. van Dyk
  • H. G. Luus
  • G. Groenewoud
Short Communications

Summary

A double-blind cross-over study was performed in 12 healthy female volunteers comparing cetirizine di-HCl (10 mg) and sustained release dexchlorpheniramine maleate (6 mg) with respect to attentuation of histamine-induced skin wheals and subjective central nervous system (CNS) effects. Cetirizine was significantly more effective than dexchlorpheniramine in suppressing the size of wheals from 2 to 24 h after drug administration. In fact, at 24 h cetirizine was still as affective as 2 h after ingestion. Ten subjects receiving dexchlorpheniramine reported subjective symptoms relating to CNS depression, in contrast to only one subject given cetirizine.

Key words

H1 antagonists cetirizine dexchlorpheniramine skin wheal CNS depression 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    De Vos C, Maleux MR, Baltes E, Gobert J (1985) Inhibition of histamine skin reaction in four animal species by UCB PO71 (Cetirizine 2HCl). Ann Allergy 55 (part II): 392Google Scholar
  2. 2.
    Rihoux JP, de Vos C, Baltes E, Delaunoy J (1985) Pharmacoclinical investigation of cetirizine, a new potent and well tolerated anti-Hl1. Ann Allergy 55 (part II): 392Google Scholar
  3. 3.
    Fadel R, Herpin-Richard N, Rihoux JP, Henocq E (1987) Inhibitory effect of cetirizine 2HCl on eosinophil migration in vivo. Clin Allergy 17: 374–379Google Scholar
  4. 4.
    Harvey RP, Schocket AL (1980) The effect of H1 and H2 blockade on cutaneous histamine response in man. J Allergy Clin Immunol 65: 136–139Google Scholar
  5. 5.
    Moser L, Hüther KJ, Koch-Weser J, Lundt PV (1978) Effects of terfenadine and diphenhydramine alone or in combination with diazepam or alcohol on psychomotor performance and subjective feelings. Eur J Clin Pharmacol 14: 417–423Google Scholar
  6. 6.
    Kulshrestha VK, Gupta PP, Turner P, Wadsworth J (1978) Some clinical pharmacological studies with terfenadine, a new antihistamine drug. Br J Clin Pharmacol 6: 25–29Google Scholar
  7. 7.
    Levander S, Hägermark O, Stahle M (1985) Peripheral antihistamine and central sedative effect of three H1-receptor antagonists. Eur J Clin Pharmacol 28: 523–529Google Scholar
  8. 8.
    Rihoux JP, Dupont P (1987) Comparative study of the peripheral and central effect of terfenadine and cetirizine 2HCl. Ann Allergy 59: 235–238Google Scholar
  9. 9.
    Phillips MJ, Meyrick Thomas RH, Moodley I, Davies RJ (1983) A comparison of the in vivo effects of ketotifen, clemastine, chlorpheniramine and sodium cromoglycate on histamine and allergen induced wheals in human skin. Br J Clin Pharmacol 15: 277–286Google Scholar

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • F. O. Müller
    • 1
  • J. J.deK Botha
    • 1
  • M. van Dyk
    • 1
  • H. G. Luus
    • 1
  • G. Groenewoud
    • 1
  1. 1.Department of PharmacologyUniversity of the Orange Free StateBloemfonteinRepublic of South Africa

Personalised recommendations