European Journal of Clinical Pharmacology

, Volume 35, Issue 3, pp 319–321

Attenuation of cutaneous reactivity to histamine by cetirizine and dexchlorpheniramine

  • F. O. Müller
  • J. J.deK Botha
  • M. van Dyk
  • H. G. Luus
  • G. Groenewoud
Short Communications

DOI: 10.1007/BF00558272

Cite this article as:
Müller, F.O., Botha, J.J., van Dyk, M. et al. Eur J Clin Pharmacol (1988) 35: 319. doi:10.1007/BF00558272

Summary

A double-blind cross-over study was performed in 12 healthy female volunteers comparing cetirizine di-HCl (10 mg) and sustained release dexchlorpheniramine maleate (6 mg) with respect to attentuation of histamine-induced skin wheals and subjective central nervous system (CNS) effects. Cetirizine was significantly more effective than dexchlorpheniramine in suppressing the size of wheals from 2 to 24 h after drug administration. In fact, at 24 h cetirizine was still as affective as 2 h after ingestion. Ten subjects receiving dexchlorpheniramine reported subjective symptoms relating to CNS depression, in contrast to only one subject given cetirizine.

Key words

H1 antagonists cetirizine dexchlorpheniramine skin wheal CNS depression 

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • F. O. Müller
    • 1
  • J. J.deK Botha
    • 1
  • M. van Dyk
    • 1
  • H. G. Luus
    • 1
  • G. Groenewoud
    • 1
  1. 1.Department of PharmacologyUniversity of the Orange Free StateBloemfonteinRepublic of South Africa

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