European Journal of Clinical Pharmacology

, Volume 7, Issue 5, pp 393–395

Relationship between antihistamic activity and plasma level of diphenhydramine

  • W. Bilzer
  • U. Gundert-Remy
  • E. Weber
Originals

Summary

Plasma levels of diphenhydramine were determined by gas chromatography up to 34 h after oral administration of 50 mg to 6 healthy men. The antihistaminic activity of diphenhydramine was assessed by reduction in the area of wheals induced by intradermal injection of 5 µg histamine hydrochloride. The plasma level of drug and reduction in size of wheal were related in 4 of the 6 subjects, but not in the other two although all six had similar concentrations of the drug in plasma. In two experiments designed to measure psychometric parameters (number facility and a time evaluation test), no relationship was found between plasma levels of diphenhydramine and the performances of the subjects.

Key words

Diphenhydramine antihistamine plasma level gas chromatographic assay psychometric tests 

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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • W. Bilzer
    • 1
  • U. Gundert-Remy
    • 1
  • E. Weber
    • 1
  1. 1.Abteilung für Klinische PharmakologieMedizinische UniversitätsklinikHeidelbergGermany

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