European Journal of Clinical Pharmacology

, Volume 37, Issue 5, pp 517–520

Changes in muscle blood flow after smoking a cigarette determined by a new noninvasive method

  • F. Weber
  • M. Anlauf
  • R. -D. Müller
Originals

DOI: 10.1007/BF00558134

Cite this article as:
Weber, F., Anlauf, M. & Müller, R.D. Eur J Clin Pharmacol (1989) 37: 517. doi:10.1007/BF00558134

Summary

In 9 healthy subjects the effect of smoking one cigarette (nicotine content 0.9 mg) on blood pressure, heart rate and total and muscle blood flow in the forearm was measured.

Blood flow was measured by a new noninvasive plethysmographic method that simultaneously gives quantitative data about total and muscle blood flow.

Smoking the cigarette did not significantly affect blood pressure or heart rate. Total blood flow in the forearm did not change but the flow to the muscle was increased and resistance in this vascular bed was decreased.

The pattern of haemodynamic changes in the forearm indicates that epinephrine may be the mediator of the circulatory effects of nicotine.

Key words

nicotine epinephrine cigarette smoking total forearm blood flow muscle blood flow plethysmography 

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • F. Weber
    • 1
  • M. Anlauf
    • 1
  • R. -D. Müller
    • 1
  1. 1.Division for Renal and Hypertensive Diseases of the Center for Internal MedicineUniversity of EssenEssenGermany

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