Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Evidence for a T-cell reaction in the cutaneous sarcoid granuloma

  • 21 Accesses

  • 7 Citations

Summary

In cutaneous sarcoidosis, mononuclear cells of granuloma have been freed and characterized by immunological tests. Of these cells, 84% of them were found to be T dependent by the E rosette test. A similar value (79%) was obtained in the stroma of delayed hypersensitivity reaction, whose immunological functions are well known. However, the physiological role of the thymus dependent pupulation within granulomas must be established.

Zusammenfassung

Mononukleare Zellen von Granulomen bei cutaner Sarkoidose wurden isoliert und durch immunologische Tests charakterisiert.

84% dieser Zellen wurden durch den Rosettentest den T-Zellen zugeordnet. Ein etwa gleicher Prozentsatz (79%) wurde im Gewebe mit allergischer Spätreaktion beobachtet, deren immunologische Typisierung und Funktion gut bekannt ist. Die Rolle der thymusabhängigen Zellpopulation in Granulomen bedarf jedoch weiterer Untersuchungen.

This is a preview of subscription content, log in to check access.

References

  1. 1.

    Alario, A., Claudy, A. L., Faure, M., Thivolet, J.: Identification immunologique et cytochimique combinée des cellules nuclées du sang périphérique humain normal. Nouv. Rev. Fr. Hématol.18, 45–52 (1977)

  2. 2.

    Basten, A., Miller, J. F., Sprent, J., Pye, J.: A receptor for antibody on B lymphocytes. I. Method of detection and functional significance. J. exp. Med.135, 610–618 (1972)

  3. 3.

    Belcher, R. W., Carney, J. F., Nankervis, G. A.: Effect of sera from patients with sarcoidosis on in vitro lymphocyte response. Int. Arch. Allergy46, 183–190 (1974)

  4. 4.

    Bianco, C., Patrick, R., Nussenzweig, V.: A population of lymphocytes bearing a membrane receptor for antigen-antibody-complement complexes. I. Separation and characterization. J. exp. Med.132, 702–720 (1970)

  5. 5.

    Boyum, A.: Separation of leucocytes from blood and bone marrow. Scand. J. Clin. Lab. Invest.21, suppl.97, 77–89 (1968)

  6. 6.

    Brouet, J. C., Preud'homme, J. L., Seligmann, M.: The use of T and B membrane markers in the classification of humain leukemias with special reference to acute lymphoblastic leukemia. Blood Cells1, 81–90 (1975)

  7. 7.

    Douglas, S. D., Schmidt, M. E., Siltzbach, L. E.: Peripheral blood monocyte IgG and C3 membrane receptor activity in patients with sarcoidosis. Proc. 6th International Conference on Sarcoidosis, pp. 186–188. (Eds.) K. Iwai, I. Hosoda. Baltimore, USA: Univ. Park Press 1974

  8. 8.

    Dwyer, J. M., Mangi, R. J., Kantor, F. S.: Poor correlation between cutaneous anergy and in vitro lymphocyte competence in sarcoidosis. J. Allergy Clin.53, 69–72 (1974)

  9. 9.

    Fridman, W.H., Neauport-Sautes, C., Guimezanes, A., Gisler, R.H.: Relation between Fc receptors of activated T cells-immunoglobulin binding factor and suppression of in vitro antibody synthesis. In: Menmbrane receptors of lymphocytes, pp. 217–225. Inserm Symp. n° 1. Amsterdam: North Holland Publ. Co. 1975

  10. 10.

    Hedfors, E., Morberg, R.: Evidence for circulating immune complexes in sarcoidosis. Clin. exp. Immunol.16, 493–496 (1974a)

  11. 11.

    Hedfors, E., Holm, G., Petersson, D.: Lymphocytes subpopulations in sarcoidosis. Clin. exp. Immunol.17, 219–226 (1974b)

  12. 12.

    Hirschrnorm, K., Schreibmann, R. R., Bach, F. H., Siltzbach, L. E.: In vitro studies of lymphocytes from patients with sarcoidosis and lymphoproliferative diseases. Lancet1974 II, 842–844

  13. 13.

    Identification, enumeration and isolation of B and T lymphocytes from human peripheral blood. Report of a WHO/IARC sponsored workshop on human B and T cells. Scand. J. Immunol.5, 521–532 (1974)

  14. 14.

    Kataria, Y. P., Sagone, A. L., Lo Buglio, A. F., Bromberg, P. A.: In vitro observation on sarcoid lymphocytes and their correlation with cutaneous anergy and clinical severity of disease. Amer. Rev. Resp. Dis.108, 767–776 (1973)

  15. 15.

    Kataria, Y. P., Lo Buglio, A. F., Bromberg, P. A., Hurtubise, P. E.: Sarcoid lymphocytes: B and T cells quantitation. Ann. N.Y. Acad. Sci.278, 69–79 (1976)

  16. 16.

    Kumagai, K., Abo, T., Sekizawa, T., Sasaki, M.: Studies of surface immunoglobulins on human B lymphocytes. I. Dissociation of cell-bound immunoglobulins with acid pH or at 37°C. J. Immunol.115, 892–987 (1968)

  17. 17.

    Lay, W. H., Nussenzweig, V.: Receptors for complement on leukocytes. J. exp. Med.128, 991–1007 (1968)

  18. 18.

    Lobo, P. I., Westervelt, F. B., Horwitz, D. A.: Identification of two populations of immunoglobulin-bearing lymphocytes in man. J. Immunol.114, 116–119 (1975)

  19. 19.

    Matsuda, M., Tachibana, T.: Serum immunoglobulin levels in sarcoidosis. Proc. 6th International Conference on Sarcoidosis, pp. 198–203. (Eds.) K. Iwai, Y. Hosoda. Baltimore, USA: Univ. Park Press 1974

  20. 20.

    Preud'homme, J. L., Flandrin, G.: Identification by peroxidase staining of monocytes in surface: Immunofluorescent tests. J. Immunol.113, 1650–1653 (1974)

  21. 21.

    Ramachandar, K., Douglas, S. D., Siltzbach, L. E., Taub, R. M.: Peripheral blood lymphocyte subpopulations in sarcoidosis. Cell. Immunol16, 422–426 (1975)

  22. 22.

    Samarut, C., Revillard, J. P.: Détection par une méthode de doubles rosettes des lymphocytes T ayant des récepteurs pour le fragment Fc des IgG. In: Les Séminaires Technologiques de I'INSERM. Techniques de séparation et d'identification des lymphocytes humaines, p. 209–212. INSERM Amsterdam: North Holland Publ. Co. 1976

  23. 23.

    Siltzbach, L. E.: Significance and specificity of the Kveim reaction. Acta med. scand. (suppl.)425, 74–79 (1964

  24. 24.

    Soler, P., Basset, F., Bernaudin, J. F., Chretien, J.: Morphology and distribution of the cells of a sarcoid granuloma: ultrastructural study of serial sections. Ann. N.Y. Acad. Sci.278, 147–160 (1976)

  25. 25.

    Tannenbaum, J., Rocklin, R. E., Schur, P. H., Sheffer, A. L.: Immunological identification of subpopulations of mononuclear cells in sarcoid granulomas. Ann. N.Y. Acad. Sci.278, 136–146 (1976)

  26. 26.

    Viac, J.: Contribution à l'étude des sous-populations lymphocytaires au niveau du sant et des tissue chez l'homme et chez l'animal. Thèse Doct. Sci. Biol. n° 39, Lyon (1975)

  27. 27.

    Viac, J., Bustamante, R., Thivolet, J.: Characterization of mononuclear cells in the inflammatory infiltrates of cutaneous tumors. Brit. J. Derm. (in press)

  28. 28.

    Walker, D. M.: Identification of subpopulations of lymphocytes and macrophages in the infiltrate of Lichen planus lesions of skin and oral mucosa. Clin. exp. Immunol.25, 529–534 (1976)

  29. 29.

    Wybran, J., Carr, M. C., Fudenberg, H. H.: The human rosette forming cells as a marker of a population of thymus-derived cells. J. clin. Invest.51, 2537–2542 (1942)

  30. 30.

    Wybran, J., Fudenberg, H. H.: Thymus derived rosette forming cells. New Engl. J. Med.288, 1072–1073 (1973)

Download references

Author information

Correspondence to A. Alario.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Alario, A., Viac, J. & Thivolet, J. Evidence for a T-cell reaction in the cutaneous sarcoid granuloma. Arch. Derm. Res. 259, 135–140 (1977). https://doi.org/10.1007/BF00557953

Download citation

Keywords

  • Public Health
  • Mononuclear Cell
  • Sarcoidosis
  • Physiological Role
  • Hypersensitivity Reaction