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Development of the auricular sebaceous glands in castrate and androgen treated rabbits

Histometric Studies of the Activity of the Sebaceous Glands

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Summary

Prepuberal castration of male rabbits of the New Zealand White breed arrests growth and leads after about 10 weeks to regressive changes in the auricular sebaceous glands. Treatment of such castrates with high doses of a depot androgen preparation (Triolandren® i.m.) for 4 weeks, on the other hand, causes hyperplasia of the auricular glands, which already begins to develop after a few injections, though it does not reach its maximum until some weeks after the androgen treatment has been withdrawn. This experimental model consequently seems well suited for the evaluation of inhibitors and stimulators of the activity of the sebaceous glands.

Zusammenfassung

Die präpubertäre Orchiektomie männlicher Kaninchen (der Rasse New Zealand White) führt zu einem Wachstumsstillstand und, nach ca. 10 Wochen, zu einer Rückbildung der Auriculartalgdrüsen. Behandlung solcher Kastraten mit hohen Dosen eines Depotandrogens (Triolandren® i.m.) während 4 Wochen verursacht demgegenüber eine Hyperplasie der Auriculardrüsen, die schon nach wenigen Injektionen beginnt, ihr Maximum aber erst einige Wochen nach Abschluß der Androgengaben erreicht. Die Versuchsanordnung erscheint demnach für die Evaluierung sekundär applizierter Inhibitoren und Stimulatoren der Talgdrüsenaktivität geeignet.

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Weirich, E.G., Longauer, J. Development of the auricular sebaceous glands in castrate and androgen treated rabbits. Arch. Derm. Res. 249, 381–387 (1974). https://doi.org/10.1007/BF00557899

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Keywords

  • Public Health
  • Androgen
  • Experimental Model
  • Arrest Growth
  • Sebaceous Gland