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Pharmacokinetics of insulin and glucose in diabetics during insulin infusion. I. Basal regimen

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Conclusions

1. Simulation of the work of the pancreas by means of an insulin doser leads to hypoinsulinemia in the hepatic circulation and hyperinsulinemia in the remainder of the vascular system, so that the blood sugar concentration cannot be normalized in diabetes.

2. Deliberate creation of a normal insulin concentration by the infuser in any one compartment of the vascular system leads to above or below normal insulin concentrations in the other compartments of the vascular system and is accompanied by a raised or lowered blood sugar concentration.

3. Impossibility of normalizing the blood sugar level by insulin administration by means of an infuser at the present time is due to the inappropriate topographical character of its connection to the blood flow.

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Literature cited

  1. 1.

    J. C. Pickup and H. Keen, Diabetologia (Berlin),18, 1 (1980).

  2. 2.

    G. L. Atkins, Multicompartment Models for Biological Systems, London (1969).

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Additional information

I. M. Sechenov First Moscow Medical Institute. Translated from Meditsinskaya Tekhnika, No. 6, pp. 21–26, November–December, 1982.

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Dreval', A.V. Pharmacokinetics of insulin and glucose in diabetics during insulin infusion. I. Basal regimen. Biomed Eng 16, 190–194 (1982). https://doi.org/10.1007/BF00556184

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Keywords

  • Blood Sugar
  • Sugar
  • Blood Flow
  • Vascular System
  • Insulin Concentration