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European Journal of Clinical Pharmacology

, Volume 27, Issue 1, pp 57–59 | Cite as

Acetaminophen accumulation in pediatric patients after repeated therapeutic doses

  • M. C. Nahata
  • D. A. Powell
  • D. E. Durrell
  • M. A. Miller
Originals

Summary

Acetaminophen serum concentrations were studied in 21 infants and children with fever. The maximum serum concentrations ranged from 9.96 to 19.6 µg/ml after a single dose of 12–14 mg/kg and 13.9 to 40.1 µg/ml after a single dose of 22–27 mg/kg. Ten patients were restudied at steadystate after repeat doses had been given every 4 or 8 h for 1 to 3 days. Total area under the acetaminophen serum concentration-time curve normalized for dose averaged 0.181 (ml/min/kg)−1 after the first dose and 0.202 (ml/min/kg)−1 at steady-state (p<0.05). Five patients showed a 13 to 44% increase in the AUC; one had a 10% decrease in the AUC; and four had less than 6% change in the AUC. There was no evidence of hepatotoxicity. These data suggest that acetaminophen may accumulate after repeated therapeutic doses in children with fever.

Key words

acetaminophen pediatric patients fever therapy accumulation pharmacokinetics 

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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • M. C. Nahata
    • 1
  • D. A. Powell
    • 1
  • D. E. Durrell
    • 1
  • M. A. Miller
    • 1
  1. 1.Department of PediatricsColleges of Pharmacy and Medicine, Ohio State University and Children's HospitalColumbusUSA

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