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Cadmium, zinc, copper and metallothionein levels in the kidney and liver of humans from central Poland

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Cd, Zn, Cu, and metallothionein (MT) levels have been determined in the renal cortex and liver of 70 persons who died in Lodz and its surroundings in the years 1985–1989. The mean concentrations were: 44.9±28.6 µg Cd/g, 52.0±16.7 µg Zn/g, 2.4±1.0 µg Cu/g, 0.79±0.40 µmol Hg/g, and 3.5±1.8 µg Cd/g, 66.7±30.5 µg Zn/g, 4.9±2.1 µg Cu/g, 0.50±0.38 µmol Hg/g wet tissue in renal cortex and liver, respectively, with mean age 54.0±13.8. Smokers showed 2.4 times higher levels of Cd in the renal cortex than non-smokers. The mean body burden of Cd was 33.4±17.3 mg. Smoking increases it twofold from 22.0 mg in non-smokers to 41.8 mg in smokers.

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  1. 1.

    Piotrowski, J.K. and Coleman, D.D.: 1980, ‘Environmental Hazards of Heavy Metals: Summary Evaluation of Lead, Cadmium and Mercury’, MARC Report, No. 20.

  2. 2.

    Lantzy, R.J. and MacKenzie, F.T.: 1979, ‘Atmospheric Trace Metals: Global Cycles and Assessment of Men's Impact’, Geochim. Cosmochim. Acta 43, 511–525.

  3. 3.

    Drasch, G.A.: 1983, ‘An Increase of Cadmium Body Burden for This Century — An Investigation on Human Tissues’, Sci. Total Environ. 26, 111–119.

  4. 4.

    Friberg, L., Piscator, M., Nordberg, G.F., and Kjellström, T.: 1974, Cadmium in the Environment, 2nd edn. CRC Press Inc. Cleveland.

  5. 5.

    Vahter, M.: 1982, Assessment of Human Exposure to Lead and Cadmium through Biological Monitoring, National Swedish Institute of Environmental Medicine, Stockholm.

  6. 6.

    Ellis, K.J., Yuen, K., Yasumura, S., and Cohn, S.H.: 1984, ‘Dose Response Analysis of Cadmium in Man: Body Burden vs Kidney Disfunction’, Environ. Res. 33, 216–226.

  7. 7.

    Lauwerys, R., Hardy, R., Job, M., Buchet, J-P., Roels, H., Bruaux, P., and Rondia, D.: 1984, ‘Environmental Pollution by Cadmium and Cadmium Body Burden: An Autopsy Study’, Toxicol. Lett. 23, 287–289.

  8. 8.

    Rocls, H., Lauwerys, R., and Dardenne, A.N.: 1983, ‘The Critical Level of Cadmium in Human Renal Cortex: A Reevaluation’, Toxicol. Lett. 15, 357–360.

  9. 9.

    Chung, J., Nartey, N.O., and Cherian, M.G.: 1986, ‘Metallothionein Levels in Liver and Kidney of Canadians — A Potential Indicator of Environmental Exposure to Cadmium’, Arch. Environ. Health 41, 319–323.

  10. 10.

    Nogawa, K., Honda, R., Yamada, Y., Kido, T., Tsuritani, I., Ishizaki, M., and Yamaya, H.: 1986, ‘Critical Concentration in Kidney Cortex of Humans Exposed to Environmental Cadmium’, Environ. Res. 40, 251–260.

  11. 11.

    Thürauf, J., Schaller, K.H., Valentin, H., Welte, D., Grote, K., and Schellmann, B.: 1986, ‘Cadmium Concentrations in Autopsy Material from Differently Polluted Areas of West Germany (FRG)’, Zbl. Bakt. Hyg. B 182, 337–347.

  12. 12.

    Honda, R. and Nogawa, K.: 1987, ‘Cadmium, Zinc and Copper Relationships in Kidney and Liver of Humans Exposed to Environmental Cadmium’, Arch. Toxicol. 59, 437–442.

  13. 13.

    Summer, K.M., Drasch, G.A., and Heilmaier, H.E.: 1986, ‘Metallothionein and Cadmium in Human Kidney Cortex: Influence of Smoking’, Human Toxicol. 5, 27–33.

  14. 14.

    Drasch, G.A., Kauert, G., and Mayer, L.: 1985, ‘Cadmium Body Burden of an Occupationally Non-Burdened Population in Southern Bavaria (FRG)’, Int. Arch. Occup. Health 55, 141–148.

  15. 15.

    Elinder, C.G., Piscator, M., and Linnman, L.: 1984, ‘Cadmium and Zinc Relationship in Kidney Cortex, Liver and Pancreas’, Environ. Res. 33, 216–226.

  16. 16.

    Blanusa, M., Kralj, Z., and Bunarevic, A.: 1985, ‘Interaction of Cadmium Zinc and Copper in Relation to Smoking Habit, Age and Histopathological Findings in Human Kidney Cortex’, Arch. Toxicol. 58, 115–117.

  17. 17.

    Pandya, C.B., Parikh, D.J., Patel, T.S., Kulkarni, P.K., Sathawara, N.G., Shah, G.M., and Chatterjee, B.B.: 1985, ‘Accumulation and Interrelationship of Cadmium and Zinc in Human Kidney Cortex’, Environ. Res. 36, 81–88.

  18. 18.

    Scott, R., Anghey, E., Fell, G.S., and Quinn, M.J.: 1987, ‘Cadmium Concentration in Human Kidneys from the UK’, Human. Toxicol. 6, 111–119.

  19. 19.

    Svatengren, M., Elinder, C.G., Friberg, L., and Lind, B.: 1986, ‘Distibution and Concentration of Cadmium in Human Kidney’, Environ. Res. 39, 1–7.

  20. 20.

    Hahn, R., Ewers, U., Jerman, E., Freier, I., Brockhaus, A., and Schlipkter, H.W.: 1987, ‘Cadmium in Kidney Cortex of Inhabitants of North-West Germany: Its Relationship to Age, Sex, Smoking and Environmental Pollution by Cadmium’, Int. Arch. Occup. Environ. Health 59, 165–176.

  21. 21.

    Kido, T., Tsuritani, I., Honda, R., Yamaya, H., Ishizaki, M., Yamada, Y., and Nogawa, K.: 1988, ‘Selenium, Zinc, Copper and Cadmium Concentration in Livers and Kidneys of People Exposed to Environmental Cadmium’, J. Trace Elem. Electrolytes Health Dis. 2, 101–14.

  22. 22.

    Von Grukl, H. and Gilek, U.: 1988, ‘Untersuchungen zur Cadmiumbelastung der Bevölkerung im Raum Augsburg (Süddeutschland)’, J. Clin. Chem. Clin. Biochem. 26, 627–633.

  23. 23.

    Piotrowski, J.K., Zelazowski, A., Pasek, W., and Łęgiewski, A.: 1978, ‘Cadmium Binding in Human Kidney’, Bromat. Chem. Toksykol. XI, 323–328.

  24. 24.

    Słotwińska-Palugniok, E., and Sybirska, H.: 1984, ‘Zinc, Cadmiujm and Lead Levels in Human Kidney and Liver’, II Conference of the Polish Toxicological Society, Lódź.

  25. 25.

    Słotwińska-Palugniok, E. and Sybirska, H.: 1987, ‘Exposure to Cadmium, Lead and Zinc in the Inhabitants of Upper Silesia Based on the Metal Levels in Selected Autopsy Samples’, III Conference of the Polish Toxicological Society, Kozubnik.

  26. 26.

    Bem, E.M., Piotrowski, J.K., Sobczak-Kozłowska, M., and Dmuchowski, Cz.: 1988, ‘Cadmium, Zinc, Copper and Metallothionein Levels in Human Liver’, Int. Arch. Occup. Environ. Health 60, 413–417.

  27. 27.

    Jaworowski, Z., Bilikiewicz, J., Pietrzak-Flis, Z., and Suplińska, M.: 1988, ‘Influence of Industry on Contamination of Polish Population with Natural Radionuclides and Heavy Metals’, Arch. Ochr. Ŝrod. 1, 101–112.

  28. 28.

    Bem, E.M., Piotrowski, J.K., and Koziara, H.: 1989, ‘Cadmium and Metallothionein Levels in the Liver of Humans Exposed to Environmental Cadmium in Upper Silesia, Poland’, Toxicol. Lett. 45, 35–39.

  29. 29.

    Jakubowski, M., Trojanowska, B., Raźniewska, G., Hałatek, T., Trzcinka-Ochocka, M. and Szymczak, W.: 1990, ‘Environmental Exposure to Cadmium: Impact on Renal Function’, Toxicol. Environ. Chem. 27, 17–29.

  30. 30.

    Kulka, E., Sokołowska, D., and Dutkiewicz, T.: 1990, ‘Toxic Metals (Cd,Pb) in Blood of Children from Bieszczady Area’, IV Conference of the Polish Toxicological Society, Jastrzębia Góra.

  31. 31.

    Just, J. and Kelus, J.: 1971, ‘Cadmium in Atmospheric Air of 10 Selected Towns in Poland’, Rocz. PZH XII, 249–256.

  32. 32.

    Jakubowski, M., Raźniewska, G., Trzcinka-Ochocka, M., Trojanowska, B.: 1991, ‘Lead and Cadmium Levels among Inhabitants of Three Regions in Poland’, In press.

  33. 33.

    Bem, E.M., Tegegnework, H., and Piotrowski, J.K.: 1986, ‘The Choice of the Optimal Mineralization Method of Biological Samples for Zinc and Copper Determination’, Bromat. Chem. Toksykol. XIX, 37–41.

  34. 34.

    Żelazowski, A.J. and Piotrowski, J.K.: 1987, ‘A Modified Procedure for Determination of Metallothionein-like Proteins in Animal Tissue’, Acta Biochim. Pol. 24, 325–333.

  35. 35.

    Bronisz, H., Szost, T., Lipska, M., and Zawada, M.: 1983, ‘Cadmium Content in Cigarettes’, Bromat. Chem. Toksykol. XVI, 121–127.

  36. 36.

    Zawadzka, T., Brulińska-Ostrowska, E., Wojciechowska-Mazurek, M., Ćwiek, K., and Starska, K.: 1989, ‘Determination of Cadmium and Lead Content in Polish and Foreign Cigarettes’, Rocz. PZH XL, 145–151.

  37. 37.

    Buchet, J.P., Lauwerys, R., Roels, H., Bernard, A., Bruaux, P., Claeys, F., Ducoffre, G., de Plaen, P., Staessen, J., Amery, A., Lijnen, P., Thijs, L., Rondia, D., Sartor, F., Saint-Remy, A., and Nick, L.: 1990, ‘Renal Effects of Cadmium Body Burden of the General Population’, Lancet 336, 699–702.

  38. 38.

    Lindqvist, B., Nyström, K., Stegmayr, B., Wirell, M., and Eriksson, A.: 1989, ‘Cadmium Concentration in Human Kidney Biopsies’, Scand. J. Urol. Nephrol. 23, 213–217.

  39. 39.

    Chmielnicka, J. and Cherian, M.G.: 1986, ‘Environmental Exposure to Cadmium and Factors Affecting Trace-Element Metabolism and Metal Toxicity’, Biol. Trace Element Res. 10, 243–261.

  40. 40.

    Nabrzyski, M. and Gajewska, R.: 1982, ‘Mercury, Cadmium and Lead in Daily Food’, Roczn. PZH XXXIII, 19–26.

  41. 41.

    Buchet, J.P., Lauwerys, R., Vandevoorde, A., and Pycke, J.M.: 1983, ‘Oral Daily Intake of Cadmium, Lead, Manganese, Copper, Chromium, Mercury, Calcium, Zinc and Arsenic in Belgium: A Duplicate Meal Study’, Fd. Chem. Toxic. 21, 19–24.

  42. 42.

    Syversen, L.M.: 1975, ‘Cadmium-Binding in Human Liver and Kidney’, Arch. Environ. Health 30, 158–164.

  43. 43.

    Drasch, G.A., Kretschmer, E., Neidlinger, P., and Summer, K.H.: 1988, ‘Metallothionein in Human Liver and Kidney: Relationship to Age, Sex, Diseases and Tobacco and Alcohol Use’, J. Trace Elem. Electrolytes Health Dis. 2, 233–237.

  44. 44.

    Piotrowski, J.K., Orłowski, Cz., and Kaszper, B.W.: 1989, ‘Postmortem alterations in Tissue Binding of Cadmium in Rat’, Bromat. Chem. Toxicol. XXII, 15–18.

  45. 45.

    Oh, S.H., Deagen, J.T., Whanger, P.D., and Weswig, P.H.: 1978, ‘Biological Function of Metallothionein. V. Its Induction in Rats by Various Stresses’, Amer. J. Physiol. 234, E282-E285.

  46. 46.

    Dieter, H.H., Müller, L., Abel, J., and Summer, K.H.: 1986, ‘Determination of Cd-Thionein in Biological Materials: Comparative Standard Recovery by Five Current Methods Using Protein Nitrogen for Standard Calibration’, Toxicol. Appl. Pharmacol. 85, 380–388.

  47. 47.

    Adamska-Dyniewska, H. and Trojanowska, B.: 1981, ‘The Relationship Between Cadmium Concentration in Liver Biopsy Material and in Venous Blood’, Acta Med. Pol. 22, 319–323.

  48. 48.

    Büchler, R.H.O. and Kägi, J.H.R.: 1974, ‘Human Hepatic Metallothionein’, FEBS Lett. 39, 229–234.

  49. 49.

    Hunziker, P.E. and Kägi, J.H.R.: 1985, ‘Isolation and Characterization of Six Human Hepatic Metallothioneins’, Biochem. J. 231, 375–382.

  50. 50.

    Sumino, K., Hayakawa, K., Shibata, T., and Kitamura, S.: 1975, ‘Heavy Metals in Normal Japanese Tissues’, Arch. Environ. Health 30, 487–494.

  51. 51.

    Onosaka, S., Min, K.-S., Fukuhara, C., Tanaka, K., Tashiro, S-I., Shimizu, I., Furata, M., Yasutomi, T., Kobashi, K., and Yamamoto, K.-I.: 1986, ‘Concentrations of Metallothionein and Metals in Malignant and Non-Malignant Tissues in Human Liver’, Toxicology 38, 261–268.

  52. 52.

    Kjellström, T.: 1979, ‘Exposure and Accumulation of Cadmium in Populations from Japan, the United State, and Sweden’, Environ. Health Persp. 28, 169–197.

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This work was supported by the grant CPBR 11.12(C-56/86) from the Institute of Rural Medicine, Lublin, Poland.


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Bem, E.M., Kaszper, B.W., Orłowski, C. et al. Cadmium, zinc, copper and metallothionein levels in the kidney and liver of humans from central Poland. Environ Monit Assess 25, 1–13 (1993). https://doi.org/10.1007/BF00549788

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  • Copper
  • Zinc
  • Cadmium
  • Environmental Management
  • Renal Cortex