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Pancreatic and hepatic ultrastructure in offspring of rabbits with protein malnutrition

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Pregnant New Zealand rabbits were fed on a low-protein, low-fat, high-carbohydrate diet during the second half of gestation and during the subsequent period of lactation. Baby rabbits born to these protein-restricted does and suckled by them for two or more weeks showed loss of fur, stunted growth, fatty metamorphosis and increased glycogen storage in the liver, and atrophy of pancreatic acinear cells associated with loss of zymogen granules as well as widespread cytoplasmic vacuolization. It is suggested that the changes observed are not merely the effect of caloric restriction but also reflect a more specific nutritional deficiency (protein deficiency) transmitted by the mother rabbit to her offspring.

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Supported by a grant from the National Institutes of Health (A-2203).

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Wellmann, K.F., Adachi, M. & Volk, B.W. Pancreatic and hepatic ultrastructure in offspring of rabbits with protein malnutrition. Virchows Arch. Abt. A Path. Anat. 360, 327–337 (1973). https://doi.org/10.1007/BF00548353

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  • Public Health
  • Caloric Restriction
  • Glycogen Storage
  • Nutritional Deficiency
  • Subsequent Period