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Placental transfer of etozolin and ozolinone during the first half of gestation in man

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Summary

The placental transfer of etozolin and its pharmacologically active metabolite ozolinone was studied in 48 patients during the first (44 patients) and second (4 patients) trimester. 24 patients received a single oral dose of etozolin 400 mg 2–20 h prior to interruption of pregnancy by curettage or prostaglandin infusion. 24 other patients received 3 oral doses of etozolin 400 mg (11 patients) or 800 mg (13 patients) on 3 consecutive days, and pregnancy was terminated 2–10 h after the last dose. The fetal tissue/maternal serum and placental tissue/maternal serum ratios of etozolin and ozolinone were found to lie between 0.3 and 0.6. The serum levels were lower in pregnant than in non-pregnant patients. The low placental and fetal concentrations of etozolin and ozolinone suggest that these drugs may prove useful when a diuretic is indicated in the treatment of oedema and hypertension during pregnancy.

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Nau, H., Steldinger, R. & Ivan, E. Placental transfer of etozolin and ozolinone during the first half of gestation in man. Eur J Clin Pharmacol 23, 253–260 (1982). https://doi.org/10.1007/BF00547564

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Key words

  • etozolin
  • ozolinone
  • pregnancy
  • placental transfer
  • fetal distribution
  • serum level
  • placental level