European Journal of Clinical Pharmacology

, Volume 22, Issue 3, pp 225–228 | Cite as

Pinazepam: A precursor of N-desmethyldiazepam

  • G. M. Pacifici
  • G. F. Placidi
  • P. Fornaro
  • R. Gomeni


The plasma profile of a single oral dose of pinazepam 10 mg was studied in 6 healthy male volunteers, aged 26 to 31 years. The concentrations of the parent compound and of its metabolite in plasma were measured by gas-chromatography. The peak plasma levels of pinazepam was 36.8±5.1 ng/ml and of N-desmethyldiazepam 150±13.3 ng/ml. The plasma concentration of the metabolite become higher than that of the parent compound shortly after administration, suggesting that pinazepam acts as a prodrug.

Key words

pinazepam N-desmethyldiazepam kinetics metabolism human 


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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • G. M. Pacifici
    • 1
  • G. F. Placidi
    • 2
  • P. Fornaro
    • 2
  • R. Gomeni
    • 3
  1. 1.Istituto di Patologia GeneraleUniversity of PisaPisaItaly
  2. 2.Clinica Psichiatrica, Medical SchoolUniversity of PisaPisaItaly
  3. 3.Department of Clinical ResearchStatistics and Pharmacokinetics Unit, Synthelabo-LersParisFrance

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