European Journal of Clinical Pharmacology

, Volume 20, Issue 3, pp 215–218

Pharmacokinetics of parenteral paracetamol and its analgesic effects in post-operative dental pain

  • R. A. Seymour
  • M. D. Rawlins

DOI: 10.1007/BF00544600

Cite this article as:
Seymour, R.A. & Rawlins, M.D. Eur J Clin Pharmacol (1981) 20: 215. doi:10.1007/BF00544600


A double-blind, randomised, crossover trial was undertaken to compare the analgesic effects of a single dose of paracetamol (1000 mg i. v.) with placebo in the immediate post-operative period following removal of impacted lower third molars. There was no significant difference in the pain relief between paracetamol and placebo in the first hour following injection. Thereafter, there was significantly less pain (P<0.05) after treatment with paracetamol than after placebo. Plasma concentrations of paracetamol were measured and pharmacokinetic variables were determined. Over the four hour period of investigation there was no clear relationship between analgesia and paracetamol concentration in either central or peripheral compartments.

Key words

paracetamol acetaminophen dental pain pharmacokinetics 

Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • R. A. Seymour
    • 1
  • M. D. Rawlins
    • 2
  1. 1.Department of Operative Dental SurgeryUniversity of Newcastle upon TyneEngland
  2. 2.Wolfson Unit of Clinical PharmacologyUniversity of Newcastle upon TyneEngland

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