European Journal of Clinical Pharmacology

, Volume 28, Issue 4, pp 429–431 | Cite as

Personality and theophylline pharmacokinetics

  • S. H. D. Jackson
  • C. A. Peverel Cooper
  • T. H. Turner


Thirteen volunteers received an iv dose of theophylline followed by blood sampling for 8 h to calculate pharmacokinetic parameters. Ten patients with asthma undergoing chronic dosing with slow release aminophylline underwent 12 h of blood sampling to calculate theophylline clearance. Both groups completed an Eysenck Personality Inventory (EPI) from which was derived scores for neuroticism (N) and extroversion (E). Using multiple regression analysis no independent effect of either N or E score on theophylline clearance or half-life could be demonstrated.

Key words

theophylline asthma personality measures pharmacokinetics volunteers patients 


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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • S. H. D. Jackson
    • 1
    • 3
  • C. A. Peverel Cooper
    • 1
  • T. H. Turner
    • 2
  1. 1.Department of Clinical PharmacologyLondonEngland
  2. 2.Department of Psychological Medicine St. Bartholomew's HospitalLondonEngland
  3. 3.Division of Clinical PharmacologyUniversity of Texas Health Science Center at San AntonioSan AntonioUSA

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