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European Journal of Clinical Pharmacology

, Volume 25, Issue 1, pp 117–121 | Cite as

Pharmacokinetics of digoxin in pregnancy

  • A. M. E. Luxford
  • G. S. M. Kellaway
Originals

Summary

Digoxin-renal-clearance, creatinine-clearance, 24-h urine elimination of digoxin and serum digoxin were studied in 15 patients in the third trimester of pregnancy and 6 to 12 weeks post-partum. There was significant fall post-partum in the first three. There was also a significant fall post-partum in serum digoxin levels. This finding was unexpected, but may be due to heightened absorption exceeding increased elimination because of the physiological status in pregnancy.

Key words

serum digoxin pregnancy digoxin-renal-clearance creatinine-clearance digoxin-elimination pharmacokinetics 

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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • A. M. E. Luxford
    • 1
  • G. S. M. Kellaway
    • 1
  1. 1.Department of Pharmacology and Clinical PharmacologyUniversity of Auckland, School of MedicineAucklandNew Zealand

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