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European Journal of Clinical Pharmacology

, Volume 25, Issue 2, pp 253–261 | Cite as

Pharmacokinetics of aspirin and salicylate in elderly subjects and in patients with alcoholic liver disease

  • M. S. Roberts
  • R. H. Rumble
  • S. Wanwimolruk
  • D. Thomas
  • P. M. Brooks
Article

Summary

Plasma aspirin, salicylate and salicyluric acid concentrations were monitored in young, elderly and alcoholic subjects after ingestion of a single 1.2 g dose of soluble aspirin. The plasma aspirin, salicylate and unbound salicylate concentration-time profiles varied considerably between individual subjects. Most of the pharmacokinetic parameters derived from these profiles were not significantly different between young subjects, elderly subjects and subjects with alcoholic liver disease. Individual plasma albumin concentrations provided a better index of the unbound plasma salicylate clearances and salicylate plasma protein binding than the age of the subject or the presence of alcoholic liver disease. Highest unbound plasma salicylate concentrations were found in subjects with the lowest plasma albumin concentrations.

Key words

aspirin pharmacokinetics salicylate alcoholic liver disease young and elderly volunteers 

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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • M. S. Roberts
    • 1
    • 2
  • R. H. Rumble
    • 1
    • 2
  • S. Wanwimolruk
    • 1
    • 2
  • D. Thomas
    • 1
    • 2
  • P. M. Brooks
    • 1
    • 2
  1. 1.School of PharmacyUniversity of TasmaniaHobartAustralia
  2. 2.Departments of Medicine and Clinical PharmacologyFlinders Medical CentreAdelaideAustralia

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