European Journal of Clinical Pharmacology

, Volume 22, Issue 2, pp 137–142 | Cite as

A comparison of the psychotropic profiles of tofisopam and diazepam

  • A. Bond
  • M. Lader
Originals

Summary

Twelve normal subjects were tested on a number of measures both before and 1,3 and 5 h after 10 mg diazepam, 100 and 200 mg tofisopam and a placebo. The measures included self-ratings of mood, bodily symptoms, hostility and sleep, the electroencephalogram (EEG), reaction time, tapping, digit symbol substitution, the symbol copying test, and plasma levels. Diazepam showed a clear profile of action, producing EEG changes, pronounced sedation and psychological impairment. The last two effects were maximal at 1 h and had worn off by 5 h. The EEG was recorded at 3 h only. Tofisopam in no way resembled diazepam. It produced no changes on the EEG or psychological tests and a very mild stimulant effect was apparent on the ratings. While diazepam was easily detectable in the blood, tofisopam did not bind to benzodiazepine receptors.

Key words

tofisopam diazepam electroencephalogram sedation pro-drug 

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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • A. Bond
    • 1
  • M. Lader
    • 1
  1. 1.Department of Pharmacology, Institute of PsychiatryUniversity of LondonEngland

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