European Journal of Clinical Pharmacology

, Volume 25, Issue 5, pp 709–711 | Cite as

Kinetics of oral fluphenazine disposition in humans by GC-MS

  • K. K. Midha
  • G. McKay
  • R. Edom
  • E. D. Korchinski
  • E. M. Hawes
  • K. Hall
Short Communication

Summary

The disposition of fluphenazine was investigated in six healthy volunteers following oral administration (5 mg). Using a sensitive and specific GC-MS procedure plasma fluphenazine concentrations were measured up until 32 h after drug administration. Peak plasma concentrations varied widely (range: 0.26–1.06 ng/ml) and were observed at 2.8±0.5 h following fluphenazine administration. The apparent terminal elimination half-life of fluphenazine was 33.1±8.1 h. The area under the plasma concentration-time curve differed widely between subjects (range: 7.1–28.6 ng/ml h) suggesting large interindividual differences in the extent of fluphenazine presystemic elimination.

Key words

fluphenazine pharmacokinetics plasma concentrations intersubject differences 

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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • K. K. Midha
    • 1
  • G. McKay
  • R. Edom
  • E. D. Korchinski
  • E. M. Hawes
  • K. Hall
  1. 1.College of Pharmacy University of SaskatchewanSaskatoonCanada

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