European Journal of Clinical Pharmacology

, Volume 24, Issue 5, pp 573–577

Atenolol and metoprolol: Comparison of effects on blood pressure and serum lipoproteins, and side effects

  • S. Rössner
  • L. Weiner
Originals

Summary

Several β-blockers increase VLDL-TG and decrease HDL-cholesterol concentrations. The underlying mechanism ist not yet clear. Some studies have suggested that the effect is less pronounced during treatment with selective β-blockers. The effects of 2 such drugs, metoprolol 200 mg/day and atenolol 50 mg/day, have been compared in 50 hypertensive patients (WHO Stage I–II), mean age 47 years. Serum lipoproteins were determined in 20 patients before treatment and after treatment with either drug for 3 months. Both drugs were equally effective in reducing blood pressure. After atenolol the initial VLDL-cholesterol concentration of 1.04 mmol/l had not changed, but it rose to 1.29 mmol/l after metoprolol (p<0.05). The HDL-cholesterol concentration 1.42 mmol/l did not fall during atenolol treatment, but during metoprolol there was a small reduction to 1.31 mmol/l (p<0.05). Hyperlipoproteinaemia is common in hypertensive patients, 40% of the present group had hypertriglyceridaemia and 25% had hypercholesterolaemia. Thus, atenolol 50 mg was found not to affect lipoproteins, whereas metoprolol 200 mg increased the VLDL concentration in 75% of the patients.

Key words

beta-blockers serum lipoproteins atenolol metoprolol hypertension VLDL HDL hypertriglyceridaemia hypercholesterolaemia side effects 

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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • S. Rössner
    • 1
  • L. Weiner
    • 1
  1. 1.King Gustaf V Research InstituteStockholm and Karlskoga HospitalKarlskogaSweden

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