European Journal of Clinical Pharmacology

, Volume 34, Issue 3, pp 311–313 | Cite as

Pharmacokinetics of oxcarbazepine and 10-hydroxy-carbazepine in the newborn child of an oxcarbazepine-treated mother

  • P. Bülau
  • W. D. Paar
  • G. E. von Unruh
Short Communications


Gaschromatography — mass spectrometry (GC/MS) was used to determine plasma levels of oxcarbazepine (OCB) and its main metabolite in a newborn girl and her OCB-treated mother during the first five post partum days.

At delivery the maternal and neonatal plasma concentrations were in the same range, indicating considerable placental transfer of both substances. In spite of ingestion of both substances via breast milk, there was no accumulation in the baby. On the fifth post partum day OCB and 10-hydroxy-carbazepine (10-OH-CB) levels in plasma in the newborn were only 12 and 7%, respectively, of the values found on the first day after delivery.

Key words

oxcarbazepine newborns antiepileptic placental transfer 10-hydroxy-carbazepine pharmacokinetics breast milk transfer 


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  1. 1.
    Sillanpää M (1981) Carbamazepine. Pharmacology and clinical uses. Acta Neurol Scand 64 [Suppl 88]: 1–202Google Scholar
  2. 2.
    Krämer G, Theisohn M, Stoll KD, Wendt G (1985) Oxcarbazepin versus Carbamazepin bei gesunden Probanden. Studien zur Kinetik, zu Metabolismus und Verträglichkeit. In: Kruse R (ed) Epilepsie 84. Einhorn, Berlin, pp 379–387Google Scholar
  3. 3.
    Bülau P, Stoll KD, Fröscher W (1987) Oxcarbazepine versus carbamazepine. In: Wolf P, Dam M, Janz D, Dreifuss F (eds) Advances in epileptology, vol 16. Raven Press, New York, pp 531–536Google Scholar
  4. 4.
    Eichelbaum M, Tomson T, Tybring G, Bertilsson L (1985) Carbamazepine metabolism in man — Induction and pharmacogenetic aspects. Clin Pharmacokinet 10: 80–90Google Scholar
  5. 5.
    Lindhout D, Höppener RJEA, Meinardi H (1984) Teratogenecity of antiepileptic drug combinations with special emphasis on epoxidation (of carbamazepine). Epilepsia 25: 77–83Google Scholar
  6. 6.
    von Unruh GE, Paar WD (1986) Gas chromatographic mass spectrometric assays for oxcarbazepine and its main metabolites, 10-hydroxy-carbazepine and carbazepine-10, 11-transdiol. Biomed Env Mass Spectrom 13: 651–656Google Scholar
  7. 7.
    Nau H, Kuhnz W, Egger HJ, Rating D, Helge H (1982) Anticonvulsants during pregnancy and lactation — Transplacental, maternal and neonatal pharmacokientics. Clin Pharmacokinet 7: 508–543Google Scholar
  8. 8.
    Fröscher W, Eichelbaum M, Niesen M, Dietrich K, Rausch P (1984) Carbamazepine levels in breast milk. Ther Drug Monit 6: 266–271Google Scholar
  9. 9.
    Wagner JG, Northam JI, Alway CD, Carpenter OS (1965) Blood levels of drug at the equilibrium state after multiple dosing. Nature 207: 1301–1302Google Scholar
  10. 10.
    Palitzsch D (1983) Pädiatrie. Enke, StuttgartGoogle Scholar
  11. 11.
    Kristensen O, Klitgaard NA, Jönsson B, Sindrup S (1983) Pharmacokinetics of 10-OH-carbazepine, the main metabolite of the antiepileptic oxcarbazepine, from serum and saliva concentrations. Acta Neurol Scand 68: 145–150Google Scholar
  12. 12.
    Feldmann KF, Dörhöfer G, Faigle JW, Imhof P (1981) Pharmacokinetics and metabolism of GP 47779, the main human metabolite of oxcarbazepine (GP 47680) in animals and healthy volunteers. In: Dam M, Gram L, Penry JK (eds) Advances in epileptology: XIIth Epilepsy International Symposium. Raven Press, New York, pp 89–96Google Scholar
  13. 13.
    Rane A, Bertilsson L, Palmér L (1975) Disposition of placentally transferred carbamazepine (Tegretol) in the newborn. Eur J Clin Pharmacol 8: 283–284Google Scholar
  14. 14.
    Theisohn M, Heimann G (1982) Disposition of the antiepileptic oxcarbazepine and its metabolites in healthy volunteers. Eur J Clin Pharmacol 22: 545–551Google Scholar

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • P. Bülau
    • 1
  • W. D. Paar
    • 1
  • G. E. von Unruh
    • 1
  1. 1.Departments of Neurology/Epileptology and Internal MedicineUniversity of BonnBonn-VenusbergFederal Republic of Germany

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