European Journal of Clinical Pharmacology

, Volume 34, Issue 3, pp 311–313 | Cite as

Pharmacokinetics of oxcarbazepine and 10-hydroxy-carbazepine in the newborn child of an oxcarbazepine-treated mother

  • P. Bülau
  • W. D. Paar
  • G. E. von Unruh
Short Communications

Summary

Gaschromatography — mass spectrometry (GC/MS) was used to determine plasma levels of oxcarbazepine (OCB) and its main metabolite in a newborn girl and her OCB-treated mother during the first five post partum days.

At delivery the maternal and neonatal plasma concentrations were in the same range, indicating considerable placental transfer of both substances. In spite of ingestion of both substances via breast milk, there was no accumulation in the baby. On the fifth post partum day OCB and 10-hydroxy-carbazepine (10-OH-CB) levels in plasma in the newborn were only 12 and 7%, respectively, of the values found on the first day after delivery.

Key words

oxcarbazepine newborns antiepileptic placental transfer 10-hydroxy-carbazepine pharmacokinetics breast milk transfer 

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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • P. Bülau
    • 1
  • W. D. Paar
    • 1
  • G. E. von Unruh
    • 1
  1. 1.Departments of Neurology/Epileptology and Internal MedicineUniversity of BonnBonn-VenusbergFederal Republic of Germany

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