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Internationales Archiv für Arbeitsmedizin

, Volume 31, Issue 3, pp 209–224 | Cite as

Biological half-life of trichloroethylene and tetrachloroethylene in human subjects

  • Masayuki Ikeda
  • Toshiko Imamura
Article

Summary

The biological half-life (T 1/2) of the urinary metabolites was measured in human subjects occupationally exposed to either trichloroethylene (24 males and 6 females) or tetrachloroethylene (9 males and 4 females). The mean of the T 1/2 of total trichloro-compounds was approx. 41 hrs in the former group, the value being essentially the same as that obtained from the experimental exposure of volunteers; the mean in the latter was approx. 144 hrs, which is 3 to 4 times as long as the former. The results were supplemented with animal experiments to examine possible metabolism modulators such as the sexes, vapor concentration, repetition of exposure, and phenobarbital pretreatment. The toxicological significances of the T 1/2 determination are discussed in relation to evaluation of the threshold limit values in industrial hygiene as well as a measure to screen out subjects vulnerable to toxic substances.

Key words

Accumulation in body and toxicity Biological half-life Body burden Chloral hydrate Drug dependence Enzyme induction Phenobarbital as an inducer Tetrachloroethylene Threshold limit value Trichloroacetic acid Trichloroethanol Trichloroethylene 

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Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • Masayuki Ikeda
    • 1
  • Toshiko Imamura
    • 1
  1. 1.Department of Public HealthKyoto University Faculty of MedicineKyotoJapan

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