Internationales Archiv für Arbeitsmedizin

, Volume 30, Issue 1, pp 31–48

Beitrag zur experimentellen Knochenfluorose

  • J. Franke
  • H. Runge
  • F. Fengler
  • Ch. Wanka
Article

Zusammenfassung

Bis zu einer Versuchsdauer von 2 Jahren wurden jungen und alten Ratten zwei verschiedene Dosen Natriumfluorid mit dem Trinkwasser verabreicht. Es werden die klinischen VerÄnderungen, die röntgenologischen Befunde und die Ergebnisse der Fluorbestimmung in der Knochenasche mitgeteilt. Histologisch konnten wir am Skeletsystem Ähnliche EinzelphÄnomene wie bei der menschlichen Fluorose beobachten. Da jedoch die Resorption die Endostose und Periostose übertraf, kam es zu einer leichten Osteoporose. UrsÄchlich dafür erscheint uns die hohe Fluordosis. Abschlie\end wird über die Ergebnisse der Bestimmung der statischen Festigkeit des Fluorknochens berichtet (Bruchkraft, Bruchbiegung, ElastizitÄtsmodul und MikrohÄrte).

A contribution to experimental fluorosis in bone

Summary

Young and old rats were given two different doses of sodium fluoride in their drinking water for a duration of up to two years. The clinical changes, the x-ray findings, and the results of the fluoride analysis in the bone ash are reported. Histologically we were able to observe similar individual phenomena as in human fluorosis, but as resorption surpassed endostosis and periostosis a slight osteoporosis occured, the cause apparently being the high dosage of fluoride. Finally, the results of the determination of the static resistance of the fluorine bone (breaking point, breaking flexibility, modul of elasticity and microscopic hardness) are reported.

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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • J. Franke
    • 1
  • H. Runge
    • 1
  • F. Fengler
    • 1
  • Ch. Wanka
    • 1
  1. 1.OrthopÄdische Klinik und Poliklinik der Martin Luther-UniversitÄtHalle-Wittenberg

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