Zeitschrift für Krebsforschung

, Volume 74, Issue 4, pp 376–382 | Cite as

Synergismus der chemotherapeutischen Wirkung einer Kombination von Thymidin und Endoxan (Cyclophosphamid) beim Ehrlich-Ascites-Tumor

  • H. Osswald


Beim Ehrlich-Ascites-Tumor bewirkte die vorhergehende Thymidingabe eine überadditive Wirkung von Endoxan (Cyclophosphamid), wenn die Thymidin-Vorbehandlung 6 Std vor der Endoxan-Injektion erfolgte. Verlängerung oder Verkürzung des Zeitintervalls verringerte die chemotherapeutische Wirksamkeit der Kombination. Der mögliche Wirkungsmechanismus wird diskutiert.

Synergistic effect of the combination of thymidine and cyclophosphamide on Ehrlich-Ascites-Tumor


Thymidine-pretreatment enhanced the chemotherapeutic action of cyclophosphamide on the Ehrlich-ascites-tumor when thymidine was injected 6 hours before the application of cyclophosphamide. Elongation or shortening of the time interval between thymidine and cyclophosphamide application diminished the chemotherapeutic efficacy of the combined compounds. The possible mechanism of action is discussed.


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Copyright information

© Springer-Verlag 1970

Authors and Affiliations

  • H. Osswald
    • 1
  1. 1.Institut für experimentelle Toxikologie und Chemotherapie am Deutschen Krebsforschungszentrum HeidelbergHeidelbergDeutschland

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