Phasenkontrastmikroskopische Beobachtungen bei der Phagocytose an normalen Fibroblasten, an Zellen eines Mäusesarkoms sowie an HeLa-Zellen

May 1956, Volume 61, Issue 3, pp 263–275 | Cite as

Article

Received: 28 March 1956

Summary

1.

Previously uninjured normal human fibroblasts of a pure strain and mouse sarcoma tumor cells intensively phagocytize in vitro hemolyzed erythrocytes. HeLa (Epidermoid carcinoma)-cells similarly phagocytize but somewhat less actively.
2.

The first phase of phagocytosis, the ingestion of the red blood cell particles, proceeds in the different investigated cell types in somewhat diverse ways, this depending upon the different morphological qualities of the cell suface. Contrarily, the second phase, that of the digestion of these particles, is essentially similar in all the observed cells.
3.

In the investigated normal human fibroblasts and mouse sarcoma cells phagocytosis is noteworthy especially in the first phase for two reasons. First, the specific morphology and quality of the cells is entirely preserved, and secondly, because there is a resemblance of the dynamics of phagocytosis with those observed in neutrophiles and macrophages.
4.

Phagocytosis of hemolyzed erythrocytes is related to pinocytosis.

This is a preview of subscription content, to check access.

Unable to display preview. Download preview PDF.

1.
Ehrich, W. E.: Klin. Wschr. 1955, 315.Google Scholar
2.
Möllendorff, W. v.: Z. Zellforsch. 15, 161 (1932).Google Scholar
3.
Rossi, F.: Z. Zellforsch. 17, 760 (1933).Google Scholar
4.
Niven, J. S. F.: J. of Path. 41, 177 (1935).Google Scholar
5.
Fischer, A., u. H. Laser: Arch. exper. Zellforsch. 3, 363 (1927).Google Scholar
6.
Knake, E.: Z. Krebsforsch. 52, 269 (1942).Google Scholar
7.
Frédéric, J., et R. Robineaux: Semaine méd. (Suppl. Semaine Hôp.) 37, 25 (1953).Google Scholar
8.
Robineaux, R.: Rév. d'Hématol. 9, 364 (1954).Google Scholar
9.
Bessis, M. C.: Ann. New York Acad. Sci. 59, 986 (1955).Google Scholar
10.
Gross, L.: Proc. Soc. Exper. Biol. a. Med. 70, 656 (1949).Google Scholar
11.
Bierling, R.: Z. Krebsforsch. 60, 31 (1954).Google Scholar
12.
— Protoplasma 44, 299 (1954).Google Scholar
13.
Vollmar, H.: Z. Hyg. 124, 291 (1943).Google Scholar
14.
Lambert, R. A., and F. M. Hanes: Proc. Soc. Exper. Biol. a. Med. 8, 113 (1911).Google Scholar
15.
Lewis, W. H.: Bull. Johns Hopkins Hosp. 49, 17 (1931).Google Scholar