Modified Hopfinger analysis of the phosphodiesterase inhibiting activity of flavonoids
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Abstract
We have obtained an effective correlation equation describing the structure dependence of the activity of a number of hydroxy- and methoxy-substituted flavonoids as cAMP phosphodiesterase inhibitors. We propose an original modification of the Hopfinger method of pairwise molecular shape descriptors which uses two shape reference molecules. The data obtained may be used to predict the activity of new flavonoid molecules.
Keywords
Inhibit Activity Flavonoid Phosphodiesterase Structure Dependence Shape Descriptor
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© Plenum Publishing Corporation 1994