Archives of Dermatological Research

, Volume 277, Issue 6, pp 439–443 | Cite as

Cell-culture studies on neurofibromatosis (von Recklinghausen's disease)

III. Experiments on X-ray sensitivity
  • R. Mao
  • W. Krone
  • W. Nothdurft
  • A. Reisacher
  • H. Gall
Original Contributions
Received:

Summary

The X-ray sensitivity of strains of fibroblast-like cells derived from peripheral neurofibromas of ten patients with neurofibromatosis was compared with that of 12 strains of skin fibroblasts derived from healthy donors. Quantitative parameters of the dose-dependent reduction in colony-forming ability did not differ significantly between these two groups of strains. The cloning efficiencies of nonirradiated controls varied within the same range in strains derived from patients and from healthy donors.

Key words

Neurofibromatosis X-ray sensitivity Chromosomal breakage 
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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • R. Mao
    • 1
  • W. Krone
    • 1
  • W. Nothdurft
    • 2
  • A. Reisacher
    • 3
  • H. Gall
    • 4
  1. 1.Abteilung HumangenetikUniversität UlmUlmFederal Republic of Germany
  2. 2.Abteilung Klinische Physiologie und ArbeitsmedizinUniversität UlmUlmFederal Republic of Germany
  3. 3.Abteilung Klinische GenetikUniversität UlmUlmFederal Republic of Germany
  4. 4.Abteilung DermatologieUniversität UlmUlmFederal Republic of Germany

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