Archives of Dermatological Research

, Volume 277, Issue 5, pp 362–369 | Cite as

Nevoid malignant melanoma

  • C. Schmoeckel
  • C. E. Castro
  • O. Braun-Falco
Original Contributions

Summary

Primary cutaneous malignant melanomas with histological features suggestive of benign nevocytic nevi were studied. From a total of about 3,500 cases, 33 patients with sufficient records, histological slides, and follow-up (at least 5 years for disease-free cases) were found; 15 of them had developed metastases, and 8 had died of disseminated melanoma. Some of the following histological characteristics were always observed: cellular atypia, mitoses, infiltration of adnexa, and in the deeper dermis, infiltrative growth, pigmented tumor cells, sharply demarcated tumor nests, and the absence of maturation. Tumor thickness was the most important prognostic criterion. Clinically, the tumors corresponded to nodular and superficial spreading melanomas. It is concluded that, in rare instances, malignant melanomas strongly resemble benign melanocytic/nevocytic nevi. Such cases do not appear to have a lower degree of malignancy and should be treated as normal malignant melanomas.

Key words

Melanoma Nevi, nevocytic 

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References

  1. 1.
    Becker DW Jr, Miller CJ, Keller HB (1980) Metastatic minimal-deviation melanoma. Ann Plast Surg 4:230–237Google Scholar
  2. 2.
    Breslow A (1975) Tumor thickness, level of invasion, and node dissection in stage-I cutaneous melanoma. Ann Surg 182:572–575Google Scholar
  3. 3.
    Clark WH Jr, From L, Bernardino EA, Mihm MC (1969) The histogenesis and biologic behavior of primary human malignant melanoma of the skin. Cancer Res 29:705–726Google Scholar
  4. 4.
    From L, Hanna W, Kahn HJ, Gruss J, Marks A, Baumal R (1983) Origin of desmoplastic malignant melanoma. Hum Pathol 14:1072–1080Google Scholar
  5. 5.
    Muhlbauer JE, Margolis RJ, Mihm MC Jr, Reed RJ (1983) Minimal deviation melanoma: a histologic variant of cutaneous malignant melanoma in its vertical growth phase. J Invest Dermatol 80:3s-5sGoogle Scholar
  6. 6.
    Okun M, Dimattia A, Thompson J, Pearson SH (1974) Malignant melanoma developing from intradermal nevi. Arch Dermatol 110:599–601Google Scholar
  7. 7.
    Reed RJ (1978) Minimal deviation melanoma (consultation case). Am J Surg Pathol 2:215–220Google Scholar
  8. 8.
    Reed RJ, Leonard DD (1979) Neurotropic melanoma: a variant of desmoplastic melanoma. Am J Surg Pathol 3:301–311Google Scholar
  9. 9.
    Reed RJ, Ichinose H, Clark WH, Mihm MC Jr (1975) Common and uncommon melanocytic nevi and borderline melanomas. Semin Oncol 2:119–147Google Scholar
  10. 10.
    Reed RJ, Clark WH, Mihm MC Jr. (1981) Premalignant melanocytic dysplasia. In: Ackerman AB (ed) Pathology of malignant melanoma. Masson, New York, pp 159–183Google Scholar
  11. 11.
    Schmoeckel C, Bockelbrink A, Bockelbrink H, Braun-Falco O (1983) Low- and high-risk malignant melanoma. II. Multivariate analyses for a prognostic classification. Eur J Cancer Clin Oncol 19:237–243Google Scholar
  12. 12.
    Schmoeckel C, Bockelbrink A, Bockelbrink H, Kistler H, Braun-Falco O (1984) Low- and high-risk malignant melanoma. III. Prognostic significance of the resection margin. Eur J Cancer Clin Oncol 19:245–249Google Scholar
  13. 13.
    Warner TF, Sook Seo J, Bennett JE (1980) Minimal deviation melanoma with epidermotropic metastases arising in a congenital nevus. Am J Surg Pathol 4:175–183Google Scholar

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • C. Schmoeckel
    • 1
  • C. E. Castro
    • 1
  • O. Braun-Falco
    • 1
  1. 1.Dermatologische Klinik und Poliklinik der Universität MünchenMünchen 2Germany

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