Archives of Dermatological Research

, Volume 272, Issue 3–4, pp 311–316 | Cite as

Flushing in rosacea: A possible mechanism

  • Marcella Guarrera
  • Aurora Parodi
  • Carla Cipriani
  • Carla Divano
  • Alfredo Rebora


Flushing in rosacea has been investigated by means of (a) pharmacological inhibition of some possible chemical mediators and (b) titration of bradykinin as a possible effector directly in the blood. Clonidine-inhibited flushing was seen in all patients (mean 45%), other drugs had poorer results. Bradykinin increased in all patients at the climax of flushing (mean 60%). These findings support the hypothesis that epinephrine promotes a bradykinin release responsible for vasodilation.

Key words

Flush Rosacea Epinephrine Bradykinin Clonidine 


Die Flush-Reaktion bei Rosazea wurde (a) durch pharmakologische Hemmung einiger Mediatoren und (b) durch Titration von Bradykinin, das möglicherweise einen direkten Effektor im Blut darstellt, untersucht.

Clonidin konnte die Flush-Reaktion bei allen Patienten (durchschnittlich um 45%) hemmen. Andere Medikamente zeigten schlechtere Ergebnisse. Der Bradykininspiegel fand sich auf dem Höhepunkt der Flush-Reaktion bei allen Patienten deutlich eleviert (durchschnittlich um 60%). Diese Ergebnisse belegen die Hypothese, daß Adrenalin die Freisetzung von Bradykinin fördert und somit eine Vasodilatation bewirken kann.


Flush Rosazea Adrenalin Bradykinin Clonidin 


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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • Marcella Guarrera
    • 1
  • Aurora Parodi
    • 1
  • Carla Cipriani
    • 1
  • Carla Divano
    • 1
  • Alfredo Rebora
    • 1
  1. 1.Department of DermatologyUniversity of GenovaGenovaItaly

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