Increase of serum very low density lipoproteins in rats after administration of α-hexachlorocyclohexane

  • O. Grajewski
  • E. Oberdisse
Article

Summary

After enteral administration of 200 mg/kg α-hexachlorocyclohexane (α-HCH) female Wistar rats develop a hyperlipemia. 48 h after administration of α-HCH, serum triglycerides are increased by 300%, whereas both serum cholesterol and serum total phospholipids only increase by about 45%. Serum free fatty acids are not significantly altered. Fractionation of the serum lipoproteins by ultracentrifugation shows that the hyperlipemia is due to a fivefold increase in serum very low density lipoproteins.

Hepatic triglyceride secretion, calculated after i.v. injection of Triton WR 1339, is increased in animals pretreated with α-HCH. Corresponding to this observation, drugs known to diminish the triglyceride secretion of the liver, such as actinomycin D, cycloheximide; glucagon, orotic acid, CFT 1201, and CFT 1042 reduce the α-HCH-induced hyperlipemia.

We concluded from the results that hyperlipoproteinemia after α-HCH is due to an increased hepatic very low density lipoprotein secretion.

At the same time, the blood sugar level was decreased in fasting animals after treatment with α-HCH. Earlier experiments suggest that this effect is due to a decreased gluconeogenesis in the liver.

Key words

Hypertriglyceridemia Very low density lipoproteins Hepatic triglyceride secretion α-Hexachlorocyclohexane Hypoglycemia 

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Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • O. Grajewski
    • 1
  • E. Oberdisse
    • 1
  1. 1.Pharmakologisches Institut der Freien Universität BerlinBerlin 33

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