Decreased toxicity of d-tubocurarine after pretreatment with drugs elevating the intracellular level of c-AMP in mice

  • P. Anttila
  • H. Vapaatalo
Short Communication

Summary

The toxicity of d-tubocurarine in mice was slightly but significantly reduced after pretreatment with drugs which are known to increase the intracellular level of c-AMP. Papaverine, theophylline and ephedrine elevated the LD50 values of d-tubocurarine by 12 to 26%. The dibutyryl derivative of c-AMP as well as c-GMP were also active in this respect.

Key words

d-Tubocurarine Cyclic AMP Cyclic GMP Phosphodiesterase Inhibitors 

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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • P. Anttila
    • 1
  • H. Vapaatalo
    • 2
  1. 1.Department of PharmacologyUniversity of HelsinkiHelsinki 17Finland
  2. 2.Department of PharmacologyUniversity of OuluOulu 10Finland

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