Alpha-receptor-mediated modulation of 3H-noradrenaline release from rat brain cortex synaptosomes

  • Arie H. Mulder
  • Cees D. J. de Langen
  • Victoria de Regt
  • François Hogenboom
Short Communication
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Accepted:

Summary

The effects of oxymetazoline and noradrenaline (in the presence of desipramine) on the release of 3H-noradrenaline from rat brain cortex synaptosomes were studied using a superfusion technique. Both drugs (at 1μM concentrations) were found to reduce the depolarization-induced (15 mM K+) release of 3H-noradrenaline. The release-modulating effect of noradrenaline was antagonized by phentolamine and yohimbine.

The data provide direct evidence for the hypothesis that α-receptors modulating the release of noradrenaline are localized on varicosities of central noradrenergic neurones.

Key words

Cerebral cortex Noradrenaline release Presynaptic α-receptors Synaptosomes 
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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • Arie H. Mulder
    • 1
  • Cees D. J. de Langen
    • 1
  • Victoria de Regt
    • 1
  • François Hogenboom
    • 1
  1. 1.Department of PharmacologyFree University, Medical FacultyAmsterdamThe Netherlands

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