Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 324, Issue 3, pp 235–237 | Cite as

The action of benzodiazepine antagonist Ro 15-1788 on the effects of GABA-ergic drugs

  • Lembit H. Allikmets
  • Lembit K. Rägo
Short Communication


The interaction of Ro 15-1788 (5 mg kg−1 i.p.), a benzodiazepine antagonist, with GABA-ergic drugs muscimol (1.4 mg kg−1 i.p.), fenibut (100 mg kg−1 i.p.) and baclofen (5 mg kg−1 i.p.) was examined in behavioural and biochemical studies in rats. All the above-mentioned GABA-ergic drugs produced motor depression and with the exception of muscimol, where anti-aggressive effect was evident, fenibut and baclofen showed only slight antiagressive properties. Ro 15-1788 attenuated the motor depression produced by these compounds but potentiated their antiaggressive effect. Moreover, it was found that Ro 15-1788 itself possessed dose-related antiagressive properties. Fenibut increased, whereas muscimol and Ro 15-1788 decreased, the GABA content in the rat striatum. Ro 15-1788 and all the studied GABA-ergic compounds increased the level of the dopaminc metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) in the striatum. In spite of this no further increase of DOPAC was observed after concomitant use of Ro 15-1788 with GABA-ergic drugs. The action of investigated GABA-ergic drugs via GABA receptors linked to benzodiazepine receptors is suggested.

Key words

Benzodiazepine antagonist Ro 15-1788 GABA-ergic drugs Interaction 


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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • Lembit H. Allikmets
    • 1
  • Lembit K. Rägo
    • 1
  1. 1.Department of PharmacologyTartu State UniversityTartuEstonia, USSR

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