Histochemistry

, Volume 82, Issue 1, pp 5–8

Suggestive evidence for a functional unit between mast cells and substance P fibers in the rat diaphragm and mesentery

  • G. Skofitsch
  • J. M. Savitt
  • D. M. Jacobowitz
Article

Summary

A close spatial relationship between serotonin-containing mast cells and substance P-containing nerves was shown by immunohistochemistry using a combination of antisera specific for serotonin and substance P. This supports earlier morphological results suggesting an innervation of mast cells and pharmacological studies which postulate an influence of substance P on the release of histamine from mast cells.

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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • G. Skofitsch
    • 1
  • J. M. Savitt
    • 1
  • D. M. Jacobowitz
    • 1
  1. 1.Laboratory of Clinical ScienceNIMHBethesdaUSA

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