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Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 301, Issue 2, pp 145–147 | Cite as

The role of bile acids in phalloidin poisoning

  • M. Frimmer
  • E. Petzinger
  • U. Rufeger
  • L. B. Veil
Short Communication

Summary

Glycocholate and other bile acids inhibit the response of isolated hepatocytes to phalloidin in a concentration dependent manner. It is suggested that the inhibition is due to a block of phalloidin uptake. This interaction might explain the high specificity of phalloidin for liver tissue.

Key words

Phalloidin poisoning Isolated hepatocytes Bile acids 

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Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • M. Frimmer
    • 1
  • E. Petzinger
    • 1
  • U. Rufeger
    • 1
  • L. B. Veil
    • 1
  1. 1.Institut für Pharmakologie und Toxikologie im Fachbereich Veterinärmedizin und Tierzucht der Justus-Liebig-Universität GiessenGiessenGermany

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