Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 273, Issue 4, pp 422–426 | Cite as

Effect of halothane on the hepatic drug metabolizing system

  • I. Rietbrock
  • G. Lazarus
  • A. Otterbein
Short Communication


Pretreatment with 2 Vol.-% halothane in oxygen for 1 h once daily on 5 days significantly decreased the hexobarbital sleeping time by about 49%. The activity of the NADPH-cytochrome c reductase was increased by 33%, whereas the amount of cytochrome P450 was not altered.

A prolongation of the daily halothane exposure to 2 h increased the activity of the NADPH-cytochrome c reductase by about 60%.

Key words

Halothane Hexobarbital Sleeping Time Cytochrome P450 NADPH-Cytochrome c Reductase 


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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • I. Rietbrock
    • 1
  • G. Lazarus
    • 1
  • A. Otterbein
    • 1
  1. 1.Abteilung für Anaesthesiologie der Universität WürzburgWürzburgGermany

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