Continuous production of L-alanine from fumarate in a two-stage membrane reactor

  • Almuth-Sigrun Jandel
  • Helmut Hustedt
  • Christian Wandrey


L-alanine was produced continuously from fumaric acid by means of soluble aspartase and L-aspartate-β-decarboxylase. The two reaction steps were carried out in two membrane reactors in series at different pH and temperature. The retention of the soluble enzymes within the reactor vessels was achieved by means of ultrafiltration membranes.


Enzyme Fumarate Reactor Vessel Reaction Step Fumaric Acid 
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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • Almuth-Sigrun Jandel
    • 1
  • Helmut Hustedt
    • 2
  • Christian Wandrey
    • 1
  1. 1.Kernforschungsanlage JülichInstitut für BiotechnologieJülichFederal Republic of Germany
  2. 2.Gesellschaft für Biotechnologische ForschungBraunschweigFederal Republic of Germany

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