, Volume 55, Issue 3, pp 263–265

Hypnoticlike effects of cannabidiol in the rat

  • Jaime M. Monti

DOI: 10.1007/BF00497858

Cite this article as:
Monti, J.M. Psychopharmacology (1977) 55: 263. doi:10.1007/BF00497858


The actions of cannabidiol (CBD), one of the cannabis constituents, were assessed on the sleep-wakefulness cycle of male Wistar rats.

During acute experiments, single doses of 20 mg/kg CBD decreased slow-wave sleep (SWS) latency. After 40 mg/kg SWS time was significantly increased while wakefulness was decreased. REM sleep was not significantly modified. Following the once-daily injections of 40 mg/kg CBD for a period of 15 days, tolerance developed to all the above-mentioned effects.

Key words

Cannabidiol Cannabis sativa Slow-wave sleep Wakefulness 

Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • Jaime M. Monti
    • 1
  1. 1.Departamento de PsicobiologíaEscola Paulista de MedicinaSão PauloBrasil
  2. 2.Depto. de Farmacología y TerapéuticaHospital de ClínicasMontevideoUruguay

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