Über den Einfluß von Glucose auf den Umsatz von l-Tryptophan beim Säugling
Zusammenfassung
Es wird der Einfluß parenteral verabfolgter Glucose auf den Umsatz von l-Tryptophan beim Säugling untersucht. Höhere Glucosedosen rufen eine Verlängerung der biologischen Halbwertzeit hervor bei gleichzeitiger Abnahme des Transfer. Dabei ist die Rate der Elimination von l-Tryptophan von der Höhe der zugeführten Glucosedosis abhängig. Es besteht jedoch weder eine positive noch negative Korrelation zur Höhe des Cortisolspiegels im Plasma. Die für die Änderung der kinetischen Werte in Betracht kommenden Ursachen werden diskutiert.
The effect of glucose on the turnover of l-tryptophan in infants
Abstract
The influence of intravenous administered glucose on the turnover of l-tryptophan in infants has been studied. High doses of glucose cause a prolongation of the biological half-life with simultaneous reduction of the transfer. Moreover, the rate of elimination of l-tryptophan is dependent upon the dose of glucose administered. However, there is neither a positive nor a negative correlation with the plasma level of cortisol. The factors which influence the kinetic values are discussed.
Key words
Glucose l-tryptophan Kinetics Biological half-life Distribution coefficient Pool Transfer Plasma cortisol Intravenous nutritionPreview
Unable to display preview. Download preview PDF.
Literatur
- 1.Civen, M., Knox, W. E.: The independence of hydrocortisone and tryptophan inductions of tryptophan pyrrolase. J. biol. Chem. 234, 1787 (1959).Google Scholar
- 2.Cho-Chung, Y. S., Pitot, H. C.: Feedback control of rat liver tryptophan pyrrolase. J. biol. Chem. 242, 1192 (1967).Google Scholar
- 3.Csanyi, V., Greengard, O.: Effect of hypophysectomy and growth hormone on the inductions of rat liver tyrosinaminotransferase and tryptophan oxygenase by hydrocortisone. Arch. Biochem. Biophys. 125, 824 (1968).Google Scholar
- 4.Dost, F. H.: Grundlagen der Pharmakokinetik. Stuttgart: Thieme 1968.Google Scholar
- 5.Feigelson, P., Greengard, O.: Immunchemical evidence for increased titers of liver tryptophan pyrrolase during substrate and hormonal enzyme induction. J. biol. Chem. 237, 3714 (1962).Google Scholar
- 6.Foster, D. O., Ray, P. D., Lardy, H. A.: A paradoxical in vivo effect of the PEP-carboxycinase of rat liver. Biochemistry 5, 563 (1966).Google Scholar
- 7.Freedland, R. A., Cunliffe, T. L., Zinkl, J. G.: The effect of insulin on enzyme adaptations to diets and hormones. J. biol. Chem. 241, 5448 (1966).Google Scholar
- 8.Greengard, O., Baker, G. T.: Glucagon, starvation and the induction of liver enzymes by hydrocortisone. Science 154, 1461 (1966).Google Scholar
- 9.Harris, M. M., Harris, R. S.: Effect of insulin hypoglycemia and glucose on various amino acids in blood of mental patients. Proc. Soc. exp. Biol. (N. Y.) 64, 471 (1947).Google Scholar
- 10.Holten, D., Kenney F. T.: Regulation of tyrosin-α-ketoglutarate transaminase in rat liver. J. biol. Chem. 242, 4372 (1967).Google Scholar
- 11.Knox, W. E., Mehler, A. H.: The conversion of tryptophan kynurenine in liver. J. biol. Chem. 187, 419 (1950).Google Scholar
- 12.Llamas, R., Cerezo, H. G., Laguna, G., Dorantes, L.: Regulacion hormonal de la actividad enzimatica. Bol. estud. med. Biol. (Mex.) 25, 179 (1968).Google Scholar
- 13.Magasanik, B.: Catabolite repression. Cold Spr. Harb. Symp. quant. Biol. 26, 249 (1961).Google Scholar
- 14.Munro, H. N., Thomson, W. S. T.: Influence of glucose on amino acid metabolism. Metabolism 2, 354 (1953).Google Scholar
- 15.Pestaña, A.: Dietary and hormonal control of enzymes of amino acid catabolism in liver. Europ. J. Biochem. 11, 400 (1969).Google Scholar
- 16.Pitot, H. C., Peraino, C.: Carbohydrate repression of enzyme induction in rat liver. J. biol. Chem. 238, 1910 (1963).Google Scholar
- 17.Ray, P. D., Foster, D. O., Lardy, H. A.: Path of carbon in gluconeogenesis and lipogenesis. J. biol. Chem. 241, 3904 (1966).Google Scholar
- 18.Schmidt, F. H.: Enzymatische Methode zur Bestimmung von Blut- und Harnzucker unter Berücksichtigung von Vergleichsuntersuchungen mit klassischen Methoden. Internist 4, 554 (1963).Google Scholar
- 19.Schor, J. M., Frieden, E.: Induction of tryptophan peroxydase of rat liver by insulin and alloxan. J. biol. Chem. 233, 612 (1958).Google Scholar
- 20.Sidransky, H., Sarma, D. S. R., Bongiorno, M., Verney, E.: Effect of dietary tryptophan on hepatic polyribosomes and protein synthesis in fasted mice. J. biol. Chem. 243, 1123 (1968).Google Scholar
- 21.Spies, J. R., Chambers, D. C.: Chemical determination of tryptophan. Analyt. Chem. 20, 30 (1948).Google Scholar
- 22.Tolckmitt, W.: Über den Einfluß von Steroidpräparaten mit Hormonwirksamkeit auf den Umsatz von l-Tryptophan beim Säugling. Arch. Kinderheilk. 181, 158 (1970).Google Scholar
- 23.Yuwiler, A., Wetterberg, L., Geller, E.: Alterations in induction of tyrosine aminotransferase and tryptophan oxygenase by glucose pretreatment. Biochim. biophys. Acta (Amst.) 208, 428 (1970).Google Scholar