European Journal of Pediatrics

, Volume 128, Issue 2, pp 67–79

Renal magnesium wasting, incomplete tubular acidosis, hypercalciuria and nephrocalcinosis in siblings

  • F. Manz
  • K. Schärer
  • P. Janka
  • J. Lombeck
Article

DOI: 10.1007/BF00496992

Cite this article as:
Manz, F., Schärer, K., Janka, P. et al. Eur J Pediatr (1978) 128: 67. doi:10.1007/BF00496992

Abstract

Polyuria, hyposthenuria, hypomagnesemia, hypercalciuria, advanced nephrocalcinosis, low citrate excretion and low glomerular filtration rates were observed in two female siblings who were followed over 10 years. Acid loading revealed incomplete distal tubular acidosis. Hypomagnesemia was due to renal magnesium wasting. It is suggested that the defect in tubular transport of magnesium is an important factor in the pathogenesis of this syndrome.

Key words

Nephrocalcinosis Renal tubular acidosis Chronic renal failure Calcium Magnesium Citrate 

Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • F. Manz
    • 1
  • K. Schärer
    • 1
  • P. Janka
    • 1
  • J. Lombeck
    • 2
  1. 1.University Children's HospitalUniversity of HeidelbergHeidelberg
  2. 2.University Children's Hospital CUniversity of DüsseldorfDüsseldorfFederal Republic of Germany

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