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Virchows Archiv A

, Volume 390, Issue 3, pp 339–345 | Cite as

Morphology of foci of altered hepatocytes and naturally-occurring hepatocellular tumors in F344 rats

  • J. M. Ward
Original Articles

Summary

The morphology of liver tumors of F344 rats used as controls in carcinogenesis bioassays were studied. Foci of cellular alteration composed of hepatocytes with basophilic cytoplasm were found commonly in F344 rats, 2 years of age. Eosinophilic and vacuolated foci were considerably less common. The morphology of 67 nodular hepatic lesions indicated that 54 were neoplastic nodules and 13 hepatocellular carcinomas. The majority of these tumors were composed of basophilic hepatocytes. Some of the carcinomas appeared to arise within neoplastic nodules. No tumors metastasized.

Key words

Liver neoplasms Hepatocellular carcinoma F344 rat 

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References

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Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • J. M. Ward
    • 1
  1. 1.Tumor Pathology Branch, Carcinogenesis Testing Program, National Cancer Institute, National Toxicology ProgramNational Institutes of HealthBethesdaUSA

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