Archives of Dermatological Research

, Volume 282, Issue 2, pp 98–102

A family study of atopic dermatitis

Clinical and genetic characteristics of 188 patients and 2,151 family members
  • W. Küster
  • M. Petersen
  • E. Christophers
  • M. Goos
  • W. Sterry
Original Contributions

Summary

The history of 188 Caucasian patients with atopic dermatitis (AD) and of 2,151 family members has been analyzed. Of the AD patients 48% suffered from respiratory atopy (36% rhinitis, 28% asthma, and 15% both). AD showed by far the earliest onset of all atopic diseases: 50% of our patients had skin lesions before the age of 2 years and 60% before the age of 5 years. In contrast, symptoms of allergic asthma developed in 40% of AD patients before the age of 5 years in comparison with only 25% who had allergic rhinitis. AD affects females more frequently than males (male to female ratio 1∶1.5), regardless of whether additional respiratory atopies are present or not. In contrast, respiratory atopies develop more frequently in males than in females (male to female ratio 1.5∶1). Mothers with respiratory atopy more often have atopic children (26%) than do fathers with respiratory atopy (13%). Finally, risk figures for genetic counselling are given. In short, the general risk of developing AD (3%) and atopy (7%) increases by a factor of two with each first-degree family member already suffering from atopy.

Key words

Atopic dermatitis Family study Genetic recurrence risk Genetic counselling 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Albrecht TH (1959) Zur Familienpathologie von Asthma bronchiale und Rhinitis pollinosa. Arch Julius Klaus-Stiftung 34:1–56Google Scholar
  2. 2.
    Brachtel R, Walter H, Beck W, Hilling M (1979) Associations between atopic diseases and the polymorphic systems ABO, Kidd, Inv and red cell acid phosphatase. Hum Genet 49:337–348Google Scholar
  3. 3.
    Carter CO, Evans KA (1969) Inheritance of congenital pyloric stenosis. J Med Genet 6:233–254Google Scholar
  4. 4.
    Coca AF, Cooke RA (1923) On the classification of the phenomenon of hypersensitiveness. J Immunol 8:163–182Google Scholar
  5. 5.
    Edford-Lubs ML (1971) Allergy in 7000 twin pairs. Acta Allergol 26:249–285Google Scholar
  6. 6.
    Gerrard JW, Vickers P, Gerrard CD (1976) The familial incidence of allergic disease. Ann Allergy 36:10–15Google Scholar
  7. 7.
    Goerttler E, Schnyder UW (1975) Zur Erbprognose der Neurodermitis atopica (Prurigo Besnier), atopic dermatitis (endogenes Ekzem). Hautarzt 26:18–20Google Scholar
  8. 8.
    Hanifin JM (1982) Atopic dermatitis. J Am Acad Dermatol 6:1–13Google Scholar
  9. 9.
    Hanifin JM (1983) Atopic dermatitis. Semin Dermatol 2:5–19Google Scholar
  10. 10.
    Happle R, Schnyder UW (1982) Evidence for the Carter effect in atopy. Int Arch Allergy Appl Immunol 68:90–92Google Scholar
  11. 11.
    Kaufman HS, Frick OL (1976) The development of allergy in infants of allergic parents: a prospective study concerning the role of heredity. Ann Allergy 37:410–415Google Scholar
  12. 12.
    Kjellmann NIM (1977) Atopic disease in seven-year-old children. Acta Paediatr Scand 66:465–471Google Scholar
  13. 13.
    Lenz W (1983) Medizinische Genetik, 6th edn. Thieme, StuttgartGoogle Scholar
  14. 14.
    Lubs ML (1972) Empiric risks for genetic counseling in families with allergy. J Pediatr 80:26–31Google Scholar
  15. 15.
    MacKie RM, Dick HMA (1979) A study of HLA antigen distribution in families with atopic dermatitis. Allergy 34:19–24Google Scholar
  16. 16.
    Nelson HS (1985) The atopic diseases. Ann Allergy 55:441–447Google Scholar
  17. 17.
    Palacios JJ, Sachno R, Blaylock WK (1968) Inheritance patterns in patients with asthma, allergic rhinitis and eczema. South Med J 161:1172–1174Google Scholar
  18. 18.
    Rajka G (1960) Prurigo Besnier (atopic dermatitis) with special reference to the role of allergic factors. Acta Derm Venereol (Stockh) 40:285–306Google Scholar
  19. 19.
    Rajka G (1975) Atopic dermatitis. Major Probl Dermatol 1:2–143Google Scholar
  20. 20.
    Rajka G (1986) Natural history and clinical manifestation of atopic dermatitis. Clin Res Allergy 4:3–26Google Scholar
  21. 21.
    Ratner B, Silberman DE (1953) Critical analysis of the hereditary concept of allergy. J Allergy 24:371–378Google Scholar
  22. 22.
    Ricny D, Brunecky Z (1976) Hereditary disposition for atopic diseases. Rev Czechoslovak Med 22:145–151Google Scholar
  23. 23.
    Ring J (1983) Was ist Atopie? Fortschr Prakt Dermatol Venerol 10:103–111Google Scholar
  24. 24.
    Roth HL, Kierland RR (1964) The natural history of atopic dermatitis. Arch Dermatol 89:209–214Google Scholar
  25. 25.
    Schnyder UW (1960) Neurodermitis — Asthma — Rhinitis. Eine genetisch allergologische Studie. Karger, BaselGoogle Scholar
  26. 26.
    Schnyder UW (1970) Allergie und Genetik aus klinischer Sicht. Allerg Immunol Forsch 3:27–33Google Scholar
  27. 27.
    Schnyder UW (1972) Zur Humangenetik der Neurodermitis atopica. Arch Dermatol Res 244:347–350Google Scholar
  28. 28.
    Schultz Larsen F, Holm NV, Henningsen K (1986) Atopic dermatitis: a genetic epidemiologic study in a population based twin sample. J Am Acad Dermatol 15:487–494Google Scholar
  29. 29.
    Schwartz M (1952) Heredity in bronchial asthma. Acta Allergol [Suppl 2]Google Scholar
  30. 30.
    Smith JM (1974) Incidence of atopic disease. Med Clin North Am 58:3–24Google Scholar
  31. 31.
    Soothill JF, Stokes CR, Turner MW, Norman AP, Taylor B (1976) Predisposing factors and the development of reaginic allergy in infancy. Clin Allergy 6:305–319Google Scholar
  32. 32.
    Svejgaard E, Jakobsen B, Svejgaard A (1985) Studies of HLA-ABC and DR antigens in pure atopic dermatitis and atopic dermatitis combined with allergic respiratory disease. Acta Derm Venereol (Stockh) [Suppl] 114:72–76Google Scholar
  33. 33.
    Thorsby E, Engeset A, Lie SO (1971) HL-A antigens and susceptibility to diseases. A study of patients with acute lymphoblastic leukemia, Hodgkin's disease and childhood asthma. Tissue Antigens 1:147Google Scholar
  34. 34.
    Tips RL (1954) A study of the inheritance of atopic hypersensitivity in man. Am J Hum Genet 6:328–343Google Scholar
  35. 35.
    Van Hecke E, Leys G (1981) Evolution of atopic dermatitis. Dermatologica 163:370–375Google Scholar
  36. 36.
    Vogel F (1970) Genetische Faktoren bei Allergien. Allerg Immunol Forsch 3:15–25Google Scholar
  37. 37.
    Vogel F, Dorn H (1964) Atopische Dermatitis. In: Becker PE (ed) Humangenetik, vol 4. Thieme, Göttingen, pp 418–428Google Scholar
  38. 38.
    VoigtlÄnder V (1977) Genetik der Neurodermitis. Z Hautkr 52 [Suppl 2]: 65–71Google Scholar
  39. 39.
    Wüthrich B (1976) Pollinosis des Kindes als Prototyp einer atopischen Krankheit. Monatsschr Kinderheilkd 124:702–705Google Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • W. Küster
    • 1
  • M. Petersen
    • 2
  • E. Christophers
    • 2
  • M. Goos
    • 3
  • W. Sterry
    • 2
  1. 1.Department of DermatologyUniversity of DüsseldorfFRG
  2. 2.Department of DermatologyUniversity of KielFRG
  3. 3.Department of DermatologyUniversity of EssenFRG
  4. 4.UniversitÄtshautklinikDüsseldorf 1FRG

Personalised recommendations