Psychopharmacology

, Volume 65, Issue 1, pp 73–77

Amphetamine psychosis and psychotic symptoms

  • David S. Janowsky
  • Craig Risch
Original Investigations

Abstract

Amphetamine psychosis has been considered to be a pharmacologic model of schizophrenia. Fifteen previously reported cases were reviewed in which experimental induction of amphetamine psychosis occurred in nonschizophrenic drug abusers. Seven (possibly ten) cases manifested Schneider's first rank symptoms and all had World Health Organization Present-State Exam symptoms which discriminated schizophrenia. This observation draws further parallels between the phenomenology of amphetamine psychosis and schizophrenic symptoms.

Key words

Amphetamine Psychosis Schizophrenia Schneiderian first rank symptoms Present-state exam 

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References

  1. Angrist, B. M., Gershon, S.: Amphetamine abuse in New York City, 1966–1968. Semin. Psychiatry 1, 195–207 (1969)Google Scholar
  2. Angrist, B. M., Gershon, S.: The phenomenology of experimentally induced amphetamine psychosis: Preliminary observations. Biol. Psychiatry 2, 95–107 (1970)Google Scholar
  3. Angrist, B. M., Shopsin, B., Gershon, S.: Metabolites of monoamines in urine and cerebrospinal fluid after large dose amphetamine administration. Psychopharmacologia 26, 1–9 (1972)Google Scholar
  4. Bell, D. S.: A comparison of amphetamine psychosis and schizophrenia. Br. J. Psychiatry 3, 701–707 (1965)Google Scholar
  5. Bell, D. S.: The experimental reproduction of amphetamine psychosis. Arch. Gen. Psychiatry 29, 35–40 (1973)Google Scholar
  6. Bleuler, E.: Dementia praecox of the group of schizophrenics. J. Zinkin (trans.). New York: International University Press 14–94 (1911)Google Scholar
  7. Bowers, M. J., Freedman, D. X.: ‘Psychedelic’ experiences in acute psychoses. Arch. Gen. Psychiatry 15, 240–248 (1966)Google Scholar
  8. Carpenter, W. T., Strauss, J. S.: Cross-cultural evaluation of Schneider's first rank symptoms of schizophrenia: A report from the international pilot study of schizophrenia. Am. J. Psychiatry 131, 682–687 (1974)Google Scholar
  9. Carpenter, W. T., Strauss, J. S., Mulch, S.: Are there pathognomonic symptoms in schizophrenia? An empiric investigation of Schneider's first rank symptoms. Arch. Gen. Psychiatry 28, 847–852 (1973a)Google Scholar
  10. Carpenter, W. T., Jr., Strauss, J. S., Bartko, J. J.: Flexible system for the diagnosis of schizophrenia: Report from the WHO international pilot study of schizophrenia. Science 182, 1275–1277 (1973b)Google Scholar
  11. Carpenter, W. T., Jr., Strauss, J. S., Bartko, J. J.: Use of signs and symptoms for the identification of schizophrenic patients. Schizophr. Bull. 37–49, 76–81 (1974)Google Scholar
  12. Connell, P. H.: Amphetamine psychosis. Maudsley Monograph 5. p. 75. London: Oxford University Press 1958Google Scholar
  13. DSM II: Diagnostic and statistical manual of metal disorders, pp. 33–36. Washington, D.C.: American Psychiatric Association 1968Google Scholar
  14. Ellinwood, E. H., Jr.: Amphetamine psychosis: Description of the individuals and process. J. Nerv. Ment. Dis. 144, 273–283 (1967)Google Scholar
  15. Griffith, J. D., Cavanaugh, J., Held, J.: Dextroamphetamine: Evaluation of psychomimetic properties in man. Arch. Gen. Psychiatry 26, 97–100 (1972)Google Scholar
  16. Griffith, J. D., Cavanaugh, J. H., Held, J.: Experimental psychosis induced by the administration of d-amphetamine. In: Amphetamines and related compounds, D. Costa and S. Garattini, eds., pp. 897–904. New York: Raven 1970aGoogle Scholar
  17. Griffith, J. D., Cavanaugh, J. H., Oates, J. A.: Psychosis induced by the administration of d-amphetamine to human volunteers. In: Psychotomimetic drugs, (D. H. Efron, ed.), pp. 287–294. New York: Raven 1970bGoogle Scholar
  18. Jonsson, L. E., Sjostron, K.: a rating scale for the evaluation of the clinical course and symptomology in amphetamine psychosis. Br. J. Psychiatry 117, 661–665 (1970)Google Scholar
  19. McCabe, M. S.: Reactive psychosis and schizophrenia with good prognosis. Arch. Gen. Psychiatry 33, 571–576 (1976)Google Scholar
  20. Mellor, D. S.: First rank symptoms of schizophrenia: The frequency of schizophrenics on admission to hospital. Differences between individual first rank symptoms. Br. J. Psychiatry 117, 15–23 (1970)Google Scholar
  21. Schneider, K.: Clinical Psychopathology, M. W. Hamilton (trans.), pp. 88–144, New York: Grune and Stratton 1959Google Scholar
  22. Slater, E.: Book review of ‘Amphetamine Psychosis’ by P. H. Connell. Br. Med. J. 1, 488 (1959)Google Scholar
  23. Taylor, M. A.: Schneiderian first rank symptoms and clinical prognostic features in schizophrenia. Arch. Gen. Psychiatry 26, 64–67 (1972)Google Scholar
  24. Weiner, I. B.: Differential diagnosis in amphetamine poisoning. Psychiatr. Q. 38, 707–716 (1964)Google Scholar

Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • David S. Janowsky
    • 1
  • Craig Risch
    • 1
  1. 1.Department of PsychiatryUniversity of California at San Diego Medical SchoolLa JollaUSA

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