Biochemical Genetics

, Volume 9, Issue 2, pp 193–196 | Cite as

Location of phosphorylase kinase (Phk) in the mouse X chromosome

  • Frans Huijing
  • Eva M. Eicher
  • Douglas L. Coleman
Article

Abstract

The phosphorylase kinase deficiency (Phk) locus has been located in the mouse X chromosome, the order of genes being centromere-Bn-Phk-Ta-jp. Since the Phk locus of the mouse may be identical to the locus responsible for the X-linked phosphorylase kinase deficiency trait of man, and there may be a high degree of gene-order homology in the X chromosome of all mammals, the location of Phk in the mouse reported here may aid in locating the phosphorylase kinase gene on the X chromosome of man.

Keywords

Phosphorylase Kinase Gene Phosphorylase Kinase Phosphorylase Kinase Deficiency Deficiency Trait 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Danforth, W. H., and Lyon, J. B., Jr. (1964). Glycogenolysis during tetanic contraction of isolated mouse muscles in the presence and absence of phosphorylase a. J. Biol. Chem. 2394047.Google Scholar
  2. Green, M. C. (1966). Mutant genes and linkages. In Green, E. L. (ed.), Biology of the Laboratory Mouse, 2nd ed., McGraw-Hill, New York, p. 87.Google Scholar
  3. Green, M. C. (1972). Linkage map of the mouse. In Whitten, W. K. (ed.), Forty-third Annual Report 1971–1972, The Jackson Laboratory, Bar Harbor, Maine, p. 60.Google Scholar
  4. Huijing, F. (1970a). Phosphorylase kinase deficiency. Biochem. Genet. 4187.Google Scholar
  5. Huijing, F. (1970b). Phosphorylase kinase: Comparison between normal and deficient mice and men. In Whelan, W. J., and Schultz, J. (eds.), Miami Winter Symposia, Vol. 1: Homologies in Enzymes and Metabolic Pathways, North Holland, Amsterdam, p. 223.Google Scholar
  6. Huijing, F. (1970c). Phosphorylase kinase deficiency in mice. FEBS Letters 10328.Google Scholar
  7. Huijing, F., and Fernandes, J. (1969). X-chromosomal inheritance of liver glycogenosis with phosphorylase kinase deficiency. Am. J. Hum. Genet. 21275.Google Scholar
  8. Lyon, J. B., Jr. (1970). The X chromosome and the enzymes controlling muscle glycogen: Phosphorylase kinase. Biochem. Genet. 4169.Google Scholar
  9. Lyon, J. B., Jr., and Porter, J. (1962). The effect of pyridoxine deficiency on muscle and liver phosphorylase of two inbred strains of mice. Biochim. Biophys. Acta 58248.Google Scholar
  10. Lyon, J. B., Jr., Porter, J., and Robertson, M. (1967). Phosphorylase b kinase inheritance in mice. Science 1551550.Google Scholar
  11. Lyon, M. F. (1972). X-chromosome inactivation and developmental patterns in mammals. Biol. Rev. 471.Google Scholar
  12. Ohno, S. (1967). Sex chromosomes and sex-linked genes. In Labhart, A., Mann, T., and Samuels, L. T. (eds.), Monographs of Endocrinology, Vol. I, Springer-Verlag, Heidelberg, p. 192.Google Scholar
  13. Ohno, S. (1969). Evolution of sex chromosomes in mammals. In Roman, H. L. (ed.), Annual Review of Genetics, Annual Reviews, Inc., Palo Alto, Calif., p. 495.Google Scholar
  14. Phillips, R. J. S. (1954). Jimpy, a new totally sex-linked gene in the house mouse. Z. Vererbungslehre 86322.Google Scholar

Copyright information

© Plenum Publishing Corporation 1973

Authors and Affiliations

  • Frans Huijing
    • 1
  • Eva M. Eicher
    • 2
  • Douglas L. Coleman
    • 2
  1. 1.Department of BiochemistryUniversity of Miami School of MedicineMiami
  2. 2.The Jackson LaboratoryBar Harbor

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