Biochemical Genetics

, Volume 4, Issue 4, pp 499–508 | Cite as

The time course of development of acetylcholinesterase and choline acetyltransferase in Drosophila melanogaster

  • S. A. Dewhurst
  • R. E. McCaman
  • W. D. Kaplan


Twenty stages in the life cycle of Canton-S, a normal strain of Drosophila melanogaster, were investigated for protein content and the activities of choline acetyltransferase and acetylcholinesterase, enzymes associated with the metabolism of acetylcholine. The maximum protein content is reached at the prepupal stage. Specific activities of choline acetyltransferase and acetylcholinesterase were high in the larval stages and again in the mature fly. The activities of these enzymes expressed on a per fly basis were compared with the activities of other enzymes, previously published by other workers, expressed on the same basis. The developmental pattern of acetylcholinesterase and choline acetyltransferase differed from the patterns exhibited by the other enzymes described earlier. It was possible to relate the different enzyme patterns to known changes occurring in the life cycle of Drosophila melanogaster.


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Copyright information

© Plenum Publishing Corporation 1970

Authors and Affiliations

  • S. A. Dewhurst
    • 1
  • R. E. McCaman
    • 1
  • W. D. Kaplan
    • 2
  1. 1.Neurosciences DivisionCity of Hope Medical CenterDuarte
  2. 2.Department of BiologyCity of Hope Medical CenterDuarte

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