Biochemical Genetics

, Volume 15, Issue 11–12, pp 1181–1191 | Cite as

Induction of the alcohol-metabolizing pathway in the nematode Panagrellus redivivus: Phenotypic effects

  • Frank Kriger
  • Dan Burke
  • M. R. Samoiloff


Panagrellus redivivus when placed in 7% ethanol or methanol becomes immobile. After 1 hr the animals resume normal swimming and will grow in alcohol. The ability to recover requires ADH activity and translation, but not transcription, as determined by inhibitor studies. Recovery decreases with longer-chain alcohols, with a greater recovery for branched rather than n-alcohols. Coincident with recovery is a threefold increase in alcohol dehydrogenase and aldehyde dehydrogenase activity. A model involving posttranscriptional control of the levels of these enzymes is presented.

Key words

nematode enzyme induction alcohol dehydrogenase aldehyde dehydrogenase 


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Copyright information

© Plenum Publishing Corporation 1977

Authors and Affiliations

  • Frank Kriger
    • 1
  • Dan Burke
    • 1
  • M. R. Samoiloff
    • 1
  1. 1.GANS, Department of ZoologyUniversity of ManitobaWinnipegCanada

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