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Chemistry of Heterocyclic Compounds

, Volume 9, Issue 8, pp 1008–1012 | Cite as

Isolation and properties of the products of the covalent hydration of 4H-imidazoles

  • V. S. Kobrin
  • L. B. Volodarskii
  • L. A. Tikhonova
  • Yu. G. Putsykin
Article
  • 24 Downloads

Abstract

The neutralization of 5-hydroxy-4,4-dimethyl-2-imidazolinium chlorides yields in the free state the products of the covalent hydration of the corresponding 4H-imidazoles — 5-hydroxy-4, 4-dimethyl-2-imidazolines. On being heated, the compounds obtained undergo various transformations, depending on the presence and position of oxygen-containing functions: 5-hydroxy-2-imidazoline gives 2-acetylamino-2-methyl-1-phenylpropan-1-ol; 3,5-dihydroxy-2-imidazoline dehydrates to 4H-imidazole 3-oxide; and 1,5-dihydroxy-2-imidazolines are converted into 2,3-dihydro-4H-1,2,5-oxadiazines.

Keywords

Chloride Hydration Organic Chemistry Free State Oxadiazines 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1975

Authors and Affiliations

  • V. S. Kobrin
    • 1
  • L. B. Volodarskii
    • 1
  • L. A. Tikhonova
    • 1
  • Yu. G. Putsykin
    • 1
  1. 1.Novosibirsk Institute of Organic Chemistry, Siberian BranchAcademy of Sciences of the USSRUSSR

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