Chemistry of Heterocyclic Compounds

, Volume 5, Issue 4, pp 453–456 | Cite as

Investigations in the field of 2,1,3-thiadiazole and 2,1,3-selenadiazole

LVIII. Bromination of derivatives of benzo-2,1,3-thiadiazole in the chain
  • V. G. Pesin
  • S. A. D'yachenko


The bromination of 4-and 5-(β-carboxyethyl)benzo-2,1,3-thiadiazoles forms 4-and 5-(α-bromo-β-carboxyethyl)benzo-2,1,3-thiadiazoles. The action of 25% aqueous ammonia on these bromo derivatives forms the corresponding β-amino acids; with alcoholic alkali, derivatives of cinnamic acid are formed; and with an aqueous solution of sodium carbonate styrene derivatives are obtained. With thionyl chloride the bromine-substituted acids form the acid chlorides, which can be converted into the amides. The introduction of a nitro group into the o-position to the carboxyethyl group hinders bromination in the chain.


Chloride Amide Styrene Nitro Group Sodium Carbonate 
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Copyright information

© Consultants Bureau 1972

Authors and Affiliations

  • V. G. Pesin
    • 1
  • S. A. D'yachenko
    • 1
  1. 1.Leningrad Chemical and Pharmaceutical InstituteUSSR

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