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Chemistry of Heterocyclic Compounds

, Volume 5, Issue 4, pp 453–456 | Cite as

Investigations in the field of 2,1,3-thiadiazole and 2,1,3-selenadiazole

LVIII. Bromination of derivatives of benzo-2,1,3-thiadiazole in the chain
  • V. G. Pesin
  • S. A. D'yachenko
Article
  • 48 Downloads

Abstract

The bromination of 4-and 5-(β-carboxyethyl)benzo-2,1,3-thiadiazoles forms 4-and 5-(α-bromo-β-carboxyethyl)benzo-2,1,3-thiadiazoles. The action of 25% aqueous ammonia on these bromo derivatives forms the corresponding β-amino acids; with alcoholic alkali, derivatives of cinnamic acid are formed; and with an aqueous solution of sodium carbonate styrene derivatives are obtained. With thionyl chloride the bromine-substituted acids form the acid chlorides, which can be converted into the amides. The introduction of a nitro group into the o-position to the carboxyethyl group hinders bromination in the chain.

Keywords

Chloride Amide Styrene Nitro Group Sodium Carbonate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Consultants Bureau 1972

Authors and Affiliations

  • V. G. Pesin
    • 1
  • S. A. D'yachenko
    • 1
  1. 1.Leningrad Chemical and Pharmaceutical InstituteUSSR

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