Environmental and Ecological Statistics

, Volume 1, Issue 4, pp 303–314

Statistical analysis of bioassays, based on hazard modelling

  • J. J. M. Bedaux
  • S. A. L. M. Kooijman
Article

Abstract

A stochastic model is proposed to describe time-dependent lethal effects of toxic compounds. It is based on simple mechanistic assumptions and provides a measure for the toxicity of a chemical compound, the so-called killing rate. The killing rate seems a promising alternative for the LC50. The model also provides the no-effect level and the LC50, both as a function of exposure time. The model is applied to real data and to simulated data.

Keywords

killing rate LC50 maximum likelihood no-effect level one-compartment model quantal assay data time dependent toxicity 

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Copyright information

© Chapman & Hall 1994

Authors and Affiliations

  • J. J. M. Bedaux
    • 1
  • S. A. L. M. Kooijman
    • 1
  1. 1.Department of Theoretical BiologyVrije Universiteit AmsterdamHV AmsterdamThe Netherlands

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