Psychopharmacology

, Volume 77, Issue 3, pp 272–278

Oral behaviour induced by intranigral muscimol is unaffected by haloperidol but abolished by large lesions of superior colliculus

  • E. B. Taha
  • P. Dean
  • P. Redgrave
Original Investigations

Abstract

It has been suggested that the GABAergic striatonigral projection may form part of the efferent pathway responsible for the expression of dopamine-related oral behaviour. Consistent with this suggestion are reports that bilateral injection of the GABA agonist muscimol can produce stereotyped gnawing and biting. We report here two experiments on this effect: (1) A dose of the dopamine receptor blocker haloperidol (0.4 mg/kg), which effectively antagonised oral stereotypy induced by systemically administered apomorphine or intranigral carbachol, had no effect on either the latency or the intensity of the gnawing produced by intranigral muscimol (1 mM); (2) large lesions involving the superior colliculus which effectively suppressed the oral stereotypy induced by 8mg/kg apomorphine completely abolished the gnawing induced by intranigral injection of muscimol. Collicular lesions suppressed both the gnawing which occurred spontaneously and that elicited by a perioral probe. These findings are consistent with the view that the substantia nigra is a relay station between the caudate nucleus and the superior colliculus in an efferent pathway mediating dopamine-related oral behaviour. In addition, they raise the possibility that such behaviour is produced by the sensitisation of a collicular-mediated perioral reflex.

Key words

Substantia nigra Muscimol Oral stereotypy Haloperidol Collicular lesions Rat 

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References

  1. Arnt J, Scheel-Krüger J (1980) Intranigral GABA antagonists produce dopamine-independent biting in rats. Eur J Pharmacol 62:51–61Google Scholar
  2. Besson MJ, Kemel ML, Gauchy C, Glowinski J (1981) Asymmetric changes in GABA release in the anterior and posterior parts of both substantia nigrae during the application of ACh in one caudate nucleus. Neurosci Lett (Suppl) 7:29Google Scholar
  3. Clavier RM, Atmadja S, Fibiger HC (1976) Nigrothalamic projections in the rat as demonstrated by orthograde and retrograde tracing techniques. Brain Res Bull 1:379–384Google Scholar
  4. DiChiara G, Proceddu ML, Morelli M, Mulas ML, Gessa GL (1978) Strio-nigral and migro-thalamic GABAergic neurons as output pathways for striatal responses. In: Krogsgaard-Larsen P, Scheel-Kruger J, Kofod E (eds) GABA neurotransmitters. Munksgaard, Copenhagen, pp 464–481Google Scholar
  5. DiChiara G, Morelli M, Porceddu ML, Gessa GL (1979) Role of thalamic gamma-aminobutyrate in motor functions: Catalepsy and ipsiversive turning after intrathalamic muscimol. Neuroscience 4:1453–1465Google Scholar
  6. Faull RLM, Mehler WR (1978) The cells of origin of migrotectal, nigrothalamic and nigrostriatal projections in the rat. Neuroscience 3:989–1002Google Scholar
  7. Graybiel AM (1978) Organization of the nigrotectal connection: An experimental tracer study in the cat. Brain Res 143:339–348Google Scholar
  8. Heal JW (1975) An animal activity monitor using a microwave Doppler system. Med Biol Engineer 13:317Google Scholar
  9. Hopkins DA, Niessen LW (1976) Substantia nigra projections to the reticular formation, superior colliculus and central grey in the rat, cat and monkey. Neurosci Lett 2:253–259Google Scholar
  10. Huston JP, Nef B, Papadopoulos G, Welzl H (1980) Activation and lateralization of sensorimotor field for perioral biting reflex by intranigral GABA agonist and by systemic apomorphine in the rat. Brain Res Bull 5:745–749Google Scholar
  11. Kilpatrick IC, Starr MS (1981) Involvement of dopamine in circling response to muscimol depends on intranigral site of injection. Eur J Pharmacol 69:407–419Google Scholar
  12. Ljungberg T, Ungerstedt U (1977) Apomorphine-induced locomotion and gnawing: Evidence that the experimental design greatly influences gnawing while locomotion remains unchanged. Eur J Pharmacol 46:147–151Google Scholar
  13. Ljungberg T, Ungerstedt U (1978) Classification of neuroleptic drugs according to their ability to inhibit apomorphine-induced locomotion and gnawing: Evidence for two different mechanisms of action. Psychopharmacology 56:239–247Google Scholar
  14. Morelli M, Porceddu ML, DiChiara G (1980) Lesions of substantia nigra by kainic acid: Effects on apomorphine-induced stereotyped behaviour. Brain Res 191:67–78Google Scholar
  15. Olianas MC, De Montis GM, Mulas G, Tagliamonte A (1978) The striatal dopaminergic function is mediated by the inhibition of a nigral nondopaminergic neuronal system via a strio-nigral GABAergic pathway. Eur J Pharmacol 49:233–241Google Scholar
  16. Pellegrino LJ, Pellegrino AS, Cushman AJ (1979) A stereotaxic atlas of the rat brain. Plenum, New YorkGoogle Scholar
  17. Redgrave P, Dean P, Donohoe TP, Pope SP (1980) Superior colliculus lesions selectively attenuate apomorphine-induced oral stereotypy: A possible role for the nigrotectal pathway. Brain Res 196:541–546Google Scholar
  18. Redgrave P, Dean P, Souki W, Lewis G (1981) Gnawing and changes in reactivity produced by microinjections of picrotoxin into the superior colliculus of rats. Psychopharmacology 75:198–203Google Scholar
  19. Sahakian BJ, Robbins TW (1975) Potentiation of locomotor activity and modification of stereotypy by starvation in apomorphine-treated rats. Neuropharmacology 14:251–257Google Scholar
  20. Sahakian BJ, Robbins TW, Morgan MJ, Iversen SD (1975) The effects of psychomotor stimulants on stereotypy and locomotor activity in socially deprived and control rats. Brain Res 84:195–205Google Scholar
  21. Schallert T, DeRyck M, Teitelbaum P (1980) Atropine stereotypy as a behavioural trap: A movement subsystem and electroencephalographic analysis. J Comp Physiol Psychol 94:1–24Google Scholar
  22. Scheel-Krüger J, Arnt J, Magelund G (1977) Behavioural stimulation induced by muscimol and other GABA agonists injected into the substantia nigra. Neurosci Lett 4:351–356Google Scholar
  23. Scheel-Krüger J, Magelund G (1981) GABA in the entopeduncular nucleus and the subthalamic nucleus participates in mediating dopaminergic striatal output functions. Life Sci 29:1555–1562Google Scholar
  24. Stein BE (1981) Organization of the rodent superior colliculus: Some comparisons with other mammals. Behav Brain Res 3:175–188Google Scholar
  25. Vincent SR, Hattori T, McGeer EG (1978) The nigrotectal projection: A biochemical and ultrastructural characterization. Brain Res 151:159–164Google Scholar
  26. Taha EB, Redgrave P (1980) Neuroleptic suppression of feeding and oral stereotypy following microinjections of carbachol into substantia nigra. Neurosci Lett 20:357–361Google Scholar
  27. Tulloch IF, Arbuthnott GW, Wright AK (1978) Topographical organization of the striatonigral pathway revealed by anterograde and retrograde tracing techniques. J Anat (Lond) 127:425–441Google Scholar
  28. Wolf G (1971) Elementary histology for neuropsychologists. In: Myers RD (ed) Methods in psychobiology, vol 1. Academic, London, pp 281–300Google Scholar
  29. Wright AK, Arbuthnott GW (1980) Non-dopamine-containing efferents of the substantia nigra: The pathway to the lower brain stem. J Neural Transm 47:221–226Google Scholar

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • E. B. Taha
    • 1
  • P. Dean
    • 1
  • P. Redgrave
    • 1
  1. 1.Department of PsychologyUniversity of SheffieldSheffieldEngland

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